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Peptide record

TPDB07065

Antibacterial Antifungal Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07065
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb PD_Hemolysis ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KKWRWWLKALAKK
Physicochemical Analysis
C87H136N24O14
NDCEQGHIMFPSTYV
K
1742.19
11.85
6
0
7
+6
-1.25
-1.192
75.38
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
16500
947.08
0
Residue Composition
number
2
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
2
L
5
K
0
M
0
F
0
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 5 M: 0 F: 0 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
13
C87H136N24O14
1742.19
11.85
+6
-1.25
-1.192
Evidence Records 14 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6.3 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against E. coli ATCC 25922 (MIC 6.3 ug/ml), S. aureus ATCC 25923 or ATCC 29213 (MIC 25-50 ug/ml), S. aureus ATCC 19636 (MIC 6.3 ug/m
Evidence 2 Activity

Activity

MIC
Antibacterial
25-50 µg/mL

Target

Staphylococcus aureus ATCC 25923 or ATCC 29213

Source & Reference

dbAMP DRAMP

Other

active against E. coli ATCC 25922 (MIC 6.3 ug/ml), S. aureus ATCC 25923 or ATCC 29213 (MIC 25-50 ug/ml), S. aureus ATCC 19636 (MIC 6.3 ug/ml), P. aeruginosa Migula ATCC 27853 or 9027 (MIC 12.5
Evidence 3 Activity

Activity

MIC
Antibacterial
6.3 µg/mL

Target

Staphylococcus aureus ATCC 19636

Source & Reference

dbAMP DRAMP

Other

E. coli ATCC 25922 (MIC 6.3 ug/ml), S. aureus ATCC 25923 or ATCC 29213 (MIC 25-50 ug/ml), S. aureus ATCC 19636 (MIC 6.3 ug/ml), P. aeruginosa Migula ATCC 27853 or 9027 (MIC 12.5 ug/ml).
Evidence 4 Activity

Activity

MIC
Antibacterial
12.5 µg/mL

Target

Pseudomonas aeruginosa Migula ATCC 27853 or 9027

Source & Reference

dbAMP DRAMP

Other

aureus ATCC 25923 or ATCC 29213 (MIC 25-50 ug/ml), S. aureus ATCC 19636 (MIC 6.3 ug/ml), P. aeruginosa Migula ATCC 27853 or 9027 (MIC 12.5 ug/ml).
Evidence 5 Activity

Activity

MIC
Antifungal
6.3 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
active against E. coli ATCC 25922 (MIC 6.3 ug/ml), S. aureus ATCC 25923 or ATCC 29213 (MIC 25-50 ug/ml), S. aureus ATCC 19636 (MIC 6.3 ug/m
Evidence 6 Activity

Activity

MIC
Antifungal
25-50 µg/mL

Target

Staphylococcus aureus ATCC 25923 or ATCC 29213

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

active against E. coli ATCC 25922 (MIC 6.3 ug/ml), S. aureus ATCC 25923 or ATCC 29213 (MIC 25-50 ug/ml), S. aureus ATCC 19636 (MIC 6.3 ug/ml), P. aeruginosa Migula ATCC 27853 or 9027 (MIC 12.5
Evidence 7 Activity

Activity

MIC
Antifungal
6.3 µg/mL

Target

Staphylococcus aureus ATCC 19636

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

E. coli ATCC 25922 (MIC 6.3 ug/ml), S. aureus ATCC 25923 or ATCC 29213 (MIC 25-50 ug/ml), S. aureus ATCC 19636 (MIC 6.3 ug/ml), P. aeruginosa Migula ATCC 27853 or 9027 (MIC 12.5 ug/ml).
Evidence 8 Activity

Activity

MIC
Antifungal
12.5 µg/mL

Target

Pseudomonas aeruginosa Migula ATCC 27853 or 9027

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

aureus ATCC 25923 or ATCC 29213 (MIC 25-50 ug/ml), S. aureus ATCC 19636 (MIC 6.3 ug/ml), P. aeruginosa Migula ATCC 27853 or 9027 (MIC 12.5 ug/ml).
Evidence 9 Activity

Activity

<10% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
<10% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Rational design of tryptophan-rich antimicrobial peptides with enhanced antimicrobial activities and specificities. | Chembiochem | 2010
Evidence 10 Activity

Activity

5% Hemolysis
Toxicity
64 µg/mL
Hemolytic Cytotoxic
5% Hemolysis | 64 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design and characterization of short hybrid antimicrobial peptides from pEM-2, mastoparan-VT1, and mastoparan-B. | Chem Biol Drug Des | 2016
Evidence 11 Activity

Activity

17% Hemolysis
Toxicity
64 µg/mL
Hemolytic Cytotoxic
17% Hemolysis | 64 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Design and characterization of short hybrid antimicrobial peptides from pEM-2, mastoparan-VT1, and mastoparan-B. | Chem Biol Drug Des | 2016
Evidence 12 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Design and characterization of short hybrid antimicrobial peptides from pEM-2, mastoparan-VT1, and mastoparan-B. | Chem Biol Drug Des | 2016
Evidence 13 Activity

Activity

% Hemolysis
Toxicity
0 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.27591703] 0% hemolysis at 2 µg/ml , 5% hemolysis at 4 µg/ml , 15% hemolysis at 8 µg/ml , 55% hemolysis at 16 µg/ml , 87% hemolysis at 32 µg/ml , 92% hemolysis at 64 µg/ml against human red blood cells 0% hemolysis at 16 µg/ml , 2.5% hemolysis at 32 µg/ml , 10% hemolysis at 64 µg/ml against sheep red blood cells | Cytotoxicity: [Ref.27591703] The cell viability of HEK293 cells induced by PV is 99.1%, 99.1%, 98.3%, 94.8%, 93.9%, 87.5% and 84.1% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 µg/mL within 24h.

Target

erythrocytes

Source & Reference

NA
DRAMP
Chem Biol Drug Des. 2017 Mar 89(3):327-338. doi: 10.1111/cbdd.12864.
Evidence 14 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis