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Peptide record

TPDB07061

Antibacterial Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07061
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 13-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
WKRWVRRWKRWLR
Physicochemical Analysis
C97H146N34O14
ANDCEQGHIMFPSTY
R
2012.45
13.01
7
0
6
+7
-1.86
-1.992
52.31
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
22000
1093.20
0
Residue Composition
number
0
A
5
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
2
K
0
M
0
F
0
P
0
S
0
T
4
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 4 Y: 0 V: 1
Chemical Descriptors
13
C97H146N34O14
2012.45
13.01
+7
-1.86
-1.992
Evidence Records 8 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4 µM

Target

Escherichia coli KCTC 1682

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli KCTC 1682 (MIC 4 uM), P. aeruginosa KCTC 1637 (MIC 8 uM), S. typhimurium KCTC 1926 (MIC 2 uM), Gram+ B. subtil
Evidence 2 Activity

Activity

MIC
Antibacterial
8 µM

Target

Pseudomonas aeruginosa KCTC 1637

Source & Reference

dbAMP DRAMP

Other

Active against E. coli KCTC 1682 (MIC 4 uM), P. aeruginosa KCTC 1637 (MIC 8 uM), S. typhimurium KCTC 1926 (MIC 2 uM), Gram+ B. subtilis KCTC 3068 (MIC 4 uM), S. epidermi
Evidence 3 Activity

Activity

MIC
Antibacterial
2 µM

Target

S. typhimurium KCTC 1926

Source & Reference

dbAMP DRAMP

Other

Active against E. coli KCTC 1682 (MIC 4 uM), P. aeruginosa KCTC 1637 (MIC 8 uM), S. typhimurium KCTC 1926 (MIC 2 uM), Gram+ B. subtilis KCTC 3068 (MIC 4 uM), S. epidermidis KCTC 1917 (MIC 4 uM), and S. aure
Evidence 4 Activity

Activity

MIC
Antibacterial
4 µM

Target

B. subtilis KCTC 3068

Source & Reference

dbAMP DRAMP

Other

MIC 4 uM), P. aeruginosa KCTC 1637 (MIC 8 uM), S. typhimurium KCTC 1926 (MIC 2 uM), Gram+ B. subtilis KCTC 3068 (MIC 4 uM), S. epidermidis KCTC 1917 (MIC 4 uM), and S. aureus KCTC1621 (MIC 2 uM). Nonstandard assa
Evidence 5 Activity

Activity

MIC
Antibacterial
4 µM

Target

Staphylococcus epidermidis KCTC 1917

Source & Reference

dbAMP DRAMP

Other

(MIC 8 uM), S. typhimurium KCTC 1926 (MIC 2 uM), Gram+ B. subtilis KCTC 3068 (MIC 4 uM), S. epidermidis KCTC 1917 (MIC 4 uM), and S. aureus KCTC1621 (MIC 2 uM). Nonstandard assays: activity was measured in 1% pepto
Evidence 6 Activity

Activity

MIC
Antibacterial
2 µM

Target

Staphylococcus aureus KCTC1621

Source & Reference

dbAMP DRAMP

Other

C 2 uM), Gram+ B. subtilis KCTC 3068 (MIC 4 uM), S. epidermidis KCTC 1917 (MIC 4 uM), and S. aureus KCTC1621 (MIC 2 uM). Nonstandard assays: activity was measured in 1% peptone where LL-37 (control) is active
Evidence 7 Activity

Activity

50% Hemolysis
Toxicity
138.0 µM
Hemolytic Cytotoxic
50% Hemolysis | 138.0 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
LL-37-derived membrane-active FK-13 analogs possessing cell selectivity, anti-biofilm activity and synergy with chloramphenicol and anti-inflammatory activity. | Biochim Biophys Acta | 2017
Evidence 8 Activity

Activity

HC50
Toxicity
138.0 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.28161291] HC50=138.0 µM against human red blood cells | Cytotoxicity: [Ref.28161291] The cell viability of mouse macrophage RAW264.7 induced by FK13-a7 is 100.2%, 112.8%, 97.0%, 95.1%, 83.4% and 83.8% at peptide concentrations of 1.25, 2.5, 5, 10, 20 and 40 µM.## The cell viablity of human keratinocyte HaCaT induced by FK1

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta Biomembr. 2017 May 1859(5):722-733. doi: 10.1016/j.bbamem.2017.01.037.