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Peptide record

TPDB07059

Antibacterial Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07059
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia PD_Hemolysis
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
WKRIVRWIKRWLR
Physicochemical Analysis
C92H146N30O14
ANDCEQGHMFPSTY
R
1896.36
12.88
6
0
7
+6
-1.44
-0.885
112.31
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
16500
870.09
0
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
1
L
2
K
0
M
0
F
0
P
0
S
0
T
3
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 1 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 1
Chemical Descriptors
13
C92H146N30O14
1896.36
12.88
+6
-1.44
-0.885
Evidence Records 4 records
Evidence 1 Activity

Activity

HC50
Hemolysis
14.0 µM
[Ref.28161291] HC50=14.0 µM against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Biochim Biophys Acta Biomembr. 2017 May 1859(5):722-733. doi: 10.1016/j.bbamem.2017.01.037.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
14.0 µM
Hemolytic Cytotoxic
50% Hemolysis | 14.0 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
LL-37-derived membrane-active FK-13 analogs possessing cell selectivity, anti-biofilm activity and synergy with chloramphenicol and anti-inflammatory activity. | Biochim Biophys Acta | 2017
Evidence 3 Activity

Activity

HC50
Toxicity
14.0 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.28161291] HC50=14.0 µM against human red blood cells | Cytotoxicity: [Ref.28161291] The cell viability of mouse macrophage RAW264.7 induced by FK13-a2 is 104.5%, 101.7%, 100.4%, 77.0%, 58.9% and 15.8% at peptide concentrations of 1.25, 2.5, 5, 10, 20 and 40 µM.## The cell viablity of human keratinocyte HaCaT induced by FK

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta Biomembr. 2017 May 1859(5):722-733. doi: 10.1016/j.bbamem.2017.01.037.
Evidence 4 Hemolysis

Activity

14.0 µM
HC50
[Ref.28161291] HC50=14.0 µM against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

PD_Hemolysis
Biochim Biophys Acta Biomembr. 2017 May 1859(5):722-733. doi: 10.1016/j.bbamem.2017.01.037.
DRAMP4
PD_Hemolysis