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Peptide record

TPDB07051

Antibacterial Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07051
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 13-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RWTWRGSGRWTWR
Physicochemical Analysis
C83H115N29O17
ANDCEQHILKMFPYV
RW
1791.01
12.88
4
0
4
+4
-3.73
-1.892
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
22000
1228.36
3
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
1
S
2
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 1 T: 2 W: 4 Y: 0 V: 0
Chemical Descriptors
13
C83H115N29O17
1791.01
12.88
+4
-3.73
-1.892
Evidence Records 4 records
Evidence 1 Activity

Activity

<5% Hemolysis
Toxicity
500 µg/mL
Hemolytic Cytotoxic
<5% Hemolysis | 500 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Activity of a novel-designed antimicrobial peptide and its interaction with lipids. | J Pept Sci | 2015
Evidence 2 Activity

Activity

25% Inhibition
Toxicity
80 µg/mL
Cytotoxic
25% Inhibition | 80 | µg/mL | target cell: Human bronchial epithelial cells BEAS-2B

Target

Human bronchial epithelial cells BEAS-2B

Source & Reference

NA
DBAASP
Activity of a novel-designed antimicrobial peptide and its interaction with lipids. | J Pept Sci | 2015
Evidence 3 Activity

Activity

IC50
Toxicity
320 µg/mL
Cytotoxic
IC50 | 320 | µg/mL | target cell: Human bronchial epithelial cells BEAS-2B

Target

Human bronchial epithelial cells BEAS-2B

Source & Reference

NA
DBAASP
Activity of a novel-designed antimicrobial peptide and its interaction with lipids. | J Pept Sci | 2015
Evidence 4 Activity

Activity

% Hemolysis
Toxicity
0 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.25683050] 0% hemolysis at 8 mg/L , 3.25% hemolysis at 16 mg/L , 0% hemolysis at 32mg/L , 0% hemolysis at 64 mg/L , 0% hemolysis at 125 mg/L , 0% hemolysis at mg/L , 2.5% hemolysis at 500 mg/L against rabbit red blood cells | Cytotoxicity: [Ref.25683050] The inhibition ratio of I-RW against human bronchial epithelial cell line BEAS-2B cells is 11.3%, 2.1%, 0.5%, 6.2%, 1.5%, 8.2%, 37.4% and 51.8% at peptide concentrations of 2.5, 5, 10, 20, 40, 80, 160 and 320 µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
J Pept Sci. 2015 Apr 21(4):274-82. doi: 10.1002/psc.2728.