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Peptide record

TPDB07009

Antibacterial Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07009
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia
standard
No
A 13-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, and Peptipedia, with an available 3D structural model.
Sequence
WGIRRILKYGKRS
Physicochemical Analysis
C75H125N25O16
ANDCEQHMFPTV
R
1632.98
12.14
5
0
5
+5
0.59
-0.946
90.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
6990
428.05
2
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
2
I
1
L
2
K
0
M
0
F
0
P
1
S
0
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 1 K: 2 M: 0 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 1 V: 0
Chemical Descriptors
13
C75H125N25O16
1632.98
12.14
+5
0.59
-0.946
Evidence Records 12 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2 µM

Target

Escherichia coli ATCC 11219

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against E. coli ATCC 11219 (MIC 2 uM), P. aeruginosa ATCC 13388 (MIC 2 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC 1.2
Evidence 2 Activity

Activity

MIC
Antibacterial
2 µM

Target

Pseudomonas aeruginosa ATCC 13388

Source & Reference

dbAMP

Other

active against E. coli ATCC 11219 (MIC 2 uM), P. aeruginosa ATCC 13388 (MIC 2 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC 1.2 uM), K. pneumoniae ATCC 10031 (MIC 3
Evidence 3 Activity

Activity

MIC
Antibacterial
1.2 µM

Target

S. enterica serovar Typhimurium ATCC 14028

Source & Reference

dbAMP

Other

active against E. coli ATCC 11219 (MIC 2 uM), P. aeruginosa ATCC 13388 (MIC 2 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC 1.2 uM), K. pneumoniae ATCC 10031 (MIC 3 uM), S. aureus ATCC 6538 (MIC 2.2 uM).
Evidence 4 Activity

Activity

MIC
Antibacterial
3 µM

Target

Klebsiella pneumoniae ATCC 10031

Source & Reference

dbAMP

Other

eruginosa ATCC 13388 (MIC 2 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC 1.2 uM), K. pneumoniae ATCC 10031 (MIC 3 uM), S. aureus ATCC 6538 (MIC 2.2 uM).
Evidence 5 Activity

Activity

MIC
Antibacterial
2.2 µM

Target

Staphylococcus aureus ATCC 6538

Source & Reference

dbAMP

Other

nterica serovar Typhimurium ATCC 14028 (MIC 1.2 uM), K. pneumoniae ATCC 10031 (MIC 3 uM), S. aureus ATCC 6538 (MIC 2.2 uM).
Evidence 6 Activity

Activity

1% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
1% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relations of myxinidin, an antibacterial peptide derived from the epidermal mucus of hagfish. | Antimicrob Agents Chemother | 2013
Evidence 7 Activity

Activity

5% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
5% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relations of myxinidin, an antibacterial peptide derived from the epidermal mucus of hagfish. | Antimicrob Agents Chemother | 2013
Evidence 8 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
Structure-activity relations of myxinidin, an antibacterial peptide derived from the epidermal mucus of hagfish. | Antimicrob Agents Chemother | 2013
Evidence 9 Activity

Activity

3% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
3% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relations of myxinidin, an antibacterial peptide derived from the epidermal mucus of hagfish. | Antimicrob Agents Chemother | 2013
Evidence 10 Activity

Activity

6% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
6% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relations of myxinidin, an antibacterial peptide derived from the epidermal mucus of hagfish. | Antimicrob Agents Chemother | 2013
Evidence 11 Activity

Activity

12% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
12% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relations of myxinidin, an antibacterial peptide derived from the epidermal mucus of hagfish. | Antimicrob Agents Chemother | 2013
Evidence 12 Activity

Activity

4% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
4% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structural insights into and activity analysis of the antimicrobial peptide myxinidin. | Antimicrob Agents Chemother | 2014