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Peptide record

TPDB07006

Antibacterial Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07006
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 13-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
LLPWKWPWWKWRR
Physicochemical Analysis
C101H136N26O14
ANDCEQGHIMFSTYV
W
1938.36
12.42
4
0
7
+4
-5.87
-1.300
60.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
27500
1418.73
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
2
L
2
K
0
M
0
F
2
P
0
S
0
T
5
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 2 M: 0 F: 0 P: 2 S: 0 T: 0 W: 5 Y: 0 V: 0
Chemical Descriptors
13
C101H136N26O14
1938.36
12.42
+4
-5.87
-1.300
Evidence Records 3 records
Evidence 1 Activity

Activity

3.6% hemolysis
Toxicity
250 µg/mL
Hemolytic Cytotoxic
3.6% hemolysis | 250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae | PLoS One | 2015
Evidence 2 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human lung normal epithelial cells NL20

Target

Human lung normal epithelial cells NL20

Source & Reference

NA
DBAASP
Antimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae | PLoS One | 2015
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.26046345] The hemolytic activities of IN1 is 3.6% at 250µg/ml against human RBCs. | Cytotoxicity: [Ref.26046345] The cell viability of NL-20 cell line is not affected (<10%) below 62.5 µg/ml. The cell viability of NL-20 is 37% and 17% at peptide concentrations of 125 and 250 µg/ml.## The cell viability of WRL-68 cell line is not affected (<10%) bel

Target

erythrocytes

Source & Reference

NA
DRAMP
PLoS One. 2015 Jun 5 10(6):e0128532.