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Peptide record

TPDB07005

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07005
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF Antifungipept CAFPdb dbAMP PD_Hemolysis
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AntiCP 2.0, and other sources, with an available 3D structural model.
Sequence
LFGMALKLLKKVL
Physicochemical Analysis
C72H128N16O14S1
RNDCEQHIPSTWY
L
1473.97
10.84
3
0
9
+3
-1.28
1.354
180.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
5
L
3
K
1
M
1
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 5 K: 3 M: 1 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
13
C72H128N16O14S1
1473.97
10.84
+3
-1.28
1.354
Evidence Records 6 records
Evidence 1 Activity

Activity

IC50
Hemolysis
53 µM
Human erythrocytes: IC50=53 µM

Target

Human erythrocytes

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Peptides. 2012 Jan 33(1):18-26.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
53.0 µM
Hemolytic Cytotoxic
50% Hemolysis | 53.0 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence 3 Activity

Activity

IC50
Toxicity
27±5 µM
Cytotoxic
IC50 | 27±5 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells. | Peptides | 2012
Evidence 4 Activity

Activity

IC50
Toxicity
20±5 µM
Cytotoxic
IC50 | 20±5 | µM | target cell: Rat epithelial cells IEC-6, CRL-1592

Target

Rat epithelial cells IEC-6, CRL-1592

Source & Reference

NA
DBAASP
Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells. | Peptides | 2012
Evidence 5 Activity

Activity

IC50
Toxicity
53 µM
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: IC50=53 µM | Cytotoxicity: HUVEC: IC50=27±5 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2012 Jan 33(1):18-26.
Evidence 6 Hemolysis

Activity

53 µM
IC50
Human erythrocytes: IC50=53 µM
Hemolysis

Target

Human erythrocytes

Source & Reference

PD_Hemolysis
Peptides. 2012 Jan 33(1):18-26.
DRAMP4
PD_Hemolysis