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Peptide record

TPDB06988

Antibacterial Antifungal Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB06988
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb APD_complete PD_Hemolysis
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
ILSAIWSGIKGLL
Physicochemical Analysis
C66H111N15O16
RNDCEQHMFPTYV
IL
1370.70
10.10
1
0
8
+1
-3.36
1.500
187.69
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5500
401.26
2
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
3
I
3
L
1
K
0
M
0
F
0
P
2
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 3 L: 3 K: 1 M: 0 F: 0 P: 0 S: 2 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
13
C66H111N15O16
1370.70
10.10
+1
-3.36
1.500
Evidence Records 6 records
Evidence 1 Activity

Activity

EC50
Toxicity
73.63 µM
Cytotoxic
EC50 | 73.63 | µM | target cell: Baby Hamster Kidney cells BHK-21

Target

Baby Hamster Kidney cells BHK-21

Source & Reference

NA
DBAASP
Bioactivity of Natural and Engineered Antimicrobial Peptides from Venom of the Scorpions Urodacus yaschenkoi and U. manicatus. | Toxins (Basel) | 2017
Evidence 2 Activity

Activity

10% Hemolysis
Toxicity
26.65 µM
Hemolytic Cytotoxic
10% Hemolysis | 26.65 | µM | target cell: Pig erythrocytes

Target

Pig erythrocytes

Source & Reference

NA
DBAASP
Bioactivity of Natural and Engineered Antimicrobial Peptides from Venom of the Scorpions Urodacus yaschenkoi and U. manicatus. | Toxins (Basel) | 2017
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
138.40 µM
Hemolytic Cytotoxic
50% Hemolysis | 138.40 | µM | target cell: Pig erythrocytes

Target

Pig erythrocytes

Source & Reference

NA
DBAASP
Bioactivity of Natural and Engineered Antimicrobial Peptides from Venom of the Scorpions Urodacus yaschenkoi and U. manicatus. | Toxins (Basel) | 2017
Evidence 4 Activity

Activity

90% Hemolysis
Toxicity
718.55 µM
Hemolytic Cytotoxic
90% Hemolysis | 718.55 | µM | target cell: Pig erythrocytes

Target

Pig erythrocytes

Source & Reference

NA
DBAASP
Bioactivity of Natural and Engineered Antimicrobial Peptides from Venom of the Scorpions Urodacus yaschenkoi and U. manicatus. | Toxins (Basel) | 2017
Evidence 5 Activity

Activity

<5% Hemolysis
Toxicity
380 µM
Hemolytic Cytotoxic
<5% Hemolysis | 380 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structural Characterization of Scorpion Peptides and Their Bactericidal Activity Against Clinical Isolates of Multidrug-Resistant Bacteria. | PLoS One | 2019
Evidence 6 Hemolysis

Source & Reference

APD_complete PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.