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Peptide record

TPDB06987

Antibacterial Anticancer Antifungal Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB06987
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
FPVTWRWWKWWKG
Physicochemical Analysis
C98H123N23O15
ANDCEQHILMSY
W
1863.20
11.64
3
0
7
+3
-6.92
-0.962
22.31
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
27500
1475.96
1
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
2
K
0
M
1
F
1
P
0
S
1
T
5
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 1 P: 1 S: 0 T: 1 W: 5 Y: 0 V: 1
Chemical Descriptors
13
C98H123N23O15
1863.20
11.64
+3
-6.92
-0.962
Evidence Records 4 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
<500 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | <500 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Effects of Rationally Designed Physico-Chemical Variants of the Peptide PuroA on Biocidal Activity towards Bacterial and Mammalian Cells. | Int J Mol Sci | 2020
Evidence 2 Activity

Activity

IC50
Toxicity
>250 µg/mL
Cytotoxic
IC50 | >250 | µg/mL | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Effects of Rationally Designed Physico-Chemical Variants of the Peptide PuroA on Biocidal Activity towards Bacterial and Mammalian Cells. | Int J Mol Sci | 2020
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
>500 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >500 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Solution structure of a novel tryptophan-rich peptide with bidirectional antimicrobial activity | J Bacteriol | 2006
Evidence 4 Activity

Activity

IC50
Toxicity
250 µg/mL
Cytotoxic
IC50 | 250 | µg/mL | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Effects of Rationally Designed Physico-Chemical Variants of the Peptide PuroA on Biocidal Activity towards Bacterial and Mammalian Cells. | Int J Mol Sci | 2020