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Peptide record

TPDB06984

Antibacterial Antifungal Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB06984
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept APD_complete PD_Hemolysis
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLLSLLSLLGKLL
Physicochemical Analysis
C64H118N14O16
ARNDCEQHIMFPTWYV
L
1339.72
10.10
1
0
8
+1
-3.21
1.854
240.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
8
L
1
K
0
M
0
F
0
P
2
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 8 K: 1 M: 0 F: 0 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C64H118N14O16
1339.72
10.10
+1
-3.21
1.854
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

E. faecium ATCC51559

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against S. aureus USA300 (MIC 3.1 uM, see ref), E. faecium ATCC51559 (MIC 12.5 uM), and S. epidermidis 1457 (MIC 3.1 uM) ( Wang et al., 2018 ).
Evidence 2 Activity

Activity

MIC
Antibacterial
3.1 µM

Target

Staphylococcus epidermidis 1457

Source & Reference

dbAMP DRAMP

Other

e against S. aureus USA300 (MIC 3.1 uM, see ref), E. faecium ATCC51559 (MIC 12.5 uM), and S. epidermidis 1457 (MIC 3.1 uM) ( Wang et al., 2018 ).
Evidence 3 Activity

Activity

MIC
Antifungal
12.5 µM

Target

E. faecium ATCC51559

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against S. aureus USA300 (MIC 3.1 uM, see ref), E. faecium ATCC51559 (MIC 12.5 uM), and S. epidermidis 1457 (MIC 3.1 uM) ( Wang et al., 2018 ).
Evidence 4 Activity

Activity

MIC
Antifungal
3.1 µM

Target

Staphylococcus epidermidis 1457

Source & Reference

dbAMP DRAMP Antifungipept

Other

e against S. aureus USA300 (MIC 3.1 uM, see ref), E. faecium ATCC51559 (MIC 12.5 uM), and S. epidermidis 1457 (MIC 3.1 uM) ( Wang et al., 2018 ).
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
10.3 µM
Hemolytic Cytotoxic
50% Hemolysis | 10.3 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence 6 Hemolysis

Source & Reference

APD_complete PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.