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Peptide record

TPDB06981

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB06981
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb dbAMP 3.0 i2APP AI4AVP DRAVP 2.0 APD_complete APD_hemolytic Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLSGIVGMLGKLF
Physicochemical Analysis
C67H108N14O15S1
ARNDCEQHPTWY
GL
1381.74
10.10
1
0
8
+1
-3.26
1.669
142.31
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
3
G
0
H
1
I
3
L
1
K
1
M
2
F
0
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 1 L: 3 K: 1 M: 1 F: 2 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
13
C67H108N14O15S1
1381.74
10.10
+1
-3.26
1.669
Evidence Records 34 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against S. aureus ATCC 25923 (MIC 3 uM), E. faecalis ATCC 29212 (MIC 10 uM), B. megaterium (2 uM), Gram-negative E. coli ATCC 259
Evidence 2 Activity

Activity

MIC
Antibacterial
10 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP DRAMP

Other

Active against S. aureus ATCC 25923 (MIC 3 uM), E. faecalis ATCC 29212 (MIC 10 uM), B. megaterium (2 uM), Gram-negative E. coli ATCC 25922 or ATCC 35218 (MIC 10 uM), P. aer
Evidence 3 Activity

Activity

MIC
Antibacterial
10 µM

Target

Escherichia coli ATCC 25922 or ATCC 35218

Source & Reference

dbAMP DRAMP

Other

25923 (MIC 3 uM), E. faecalis ATCC 29212 (MIC 10 uM), B. megaterium (2 uM), Gram-negative E. coli ATCC 25922 or ATCC 35218 (MIC 10 uM), P. aeruginosa ATCC 27853 (MIC 31 uM), fungi C. albicans ATCC 90028 (MIC 16 uM), C. parap
Evidence 4 Activity

Activity

MIC
Antibacterial
31 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP

Other

10 uM), B. megaterium (2 uM), Gram-negative E. coli ATCC 25922 or ATCC 35218 (MIC 10 uM), P. aeruginosa ATCC 27853 (MIC 31 uM), fungi C. albicans ATCC 90028 (MIC 16 uM), C. parapsilosis ATCC 22019 (MIC 31 uM), and S.
Evidence 5 Activity

Activity

MIC
Antibacterial
16 µM

Target

Candida albicans ATCC 90028

Source & Reference

dbAMP DRAMP

Other

E. coli ATCC 25922 or ATCC 35218 (MIC 10 uM), P. aeruginosa ATCC 27853 (MIC 31 uM), fungi C. albicans ATCC 90028 (MIC 16 uM), C. parapsilosis ATCC 22019 (MIC 31 uM), and S. cerevisiae (MIC 8 uM). inhibited formatio
Evidence 6 Activity

Activity

MIC
Antibacterial
31 µM

Target

C. parapsilosis ATCC 22019

Source & Reference

dbAMP DRAMP

Other

C 10 uM), P. aeruginosa ATCC 27853 (MIC 31 uM), fungi C. albicans ATCC 90028 (MIC 16 uM), C. parapsilosis ATCC 22019 (MIC 31 uM), and S. cerevisiae (MIC 8 uM). inhibited formation of biofilms:fungi:C. albicans. parasit
Evidence 7 Activity

Activity

MIC
Antibacterial
8 µM

Target

S. cerevisiae

Source & Reference

dbAMP DRAMP

Other

M), fungi C. albicans ATCC 90028 (MIC 16 uM), C. parapsilosis ATCC 22019 (MIC 31 uM), and S. cerevisiae (MIC 8 uM). inhibited formation of biofilms:fungi:C. albicans. parasites L. mexicana (Molecules. 201
Evidence 8 Activity

Activity

MIC
Antifungal
3 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against S. aureus ATCC 25923 (MIC 3 uM), E. faecalis ATCC 29212 (MIC 10 uM), B. megaterium (2 uM), Gram-negative E. coli ATCC 259
Evidence 9 Activity

Activity

MIC
Antifungal
10 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against S. aureus ATCC 25923 (MIC 3 uM), E. faecalis ATCC 29212 (MIC 10 uM), B. megaterium (2 uM), Gram-negative E. coli ATCC 25922 or ATCC 35218 (MIC 10 uM), P. aer
Evidence 10 Activity

Activity

MIC
Antifungal
10 µM

Target

Escherichia coli ATCC 25922 or ATCC 35218

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

25923 (MIC 3 uM), E. faecalis ATCC 29212 (MIC 10 uM), B. megaterium (2 uM), Gram-negative E. coli ATCC 25922 or ATCC 35218 (MIC 10 uM), P. aeruginosa ATCC 27853 (MIC 31 uM), fungi C. albicans ATCC 90028 (MIC 16 uM), C. parap
Evidence 11 Activity

Activity

MIC
Antifungal
31 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

10 uM), B. megaterium (2 uM), Gram-negative E. coli ATCC 25922 or ATCC 35218 (MIC 10 uM), P. aeruginosa ATCC 27853 (MIC 31 uM), fungi C. albicans ATCC 90028 (MIC 16 uM), C. parapsilosis ATCC 22019 (MIC 31 uM), and S.
Evidence 12 Activity

Activity

MIC
Antifungal
16 µM

Target

Candida albicans ATCC 90028

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

E. coli ATCC 25922 or ATCC 35218 (MIC 10 uM), P. aeruginosa ATCC 27853 (MIC 31 uM), fungi C. albicans ATCC 90028 (MIC 16 uM), C. parapsilosis ATCC 22019 (MIC 31 uM), and S. cerevisiae (MIC 8 uM). inhibited formatio
Evidence 13 Activity

Activity

MIC
Antifungal
31 µM

Target

C. parapsilosis ATCC 22019

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

C 10 uM), P. aeruginosa ATCC 27853 (MIC 31 uM), fungi C. albicans ATCC 90028 (MIC 16 uM), C. parapsilosis ATCC 22019 (MIC 31 uM), and S. cerevisiae (MIC 8 uM). inhibited formation of biofilms:fungi:C. albicans. parasit
Evidence 14 Activity

Activity

MIC
Antifungal
8 µM

Target

S. cerevisiae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

M), fungi C. albicans ATCC 90028 (MIC 16 uM), C. parapsilosis ATCC 22019 (MIC 31 uM), and S. cerevisiae (MIC 8 uM). inhibited formation of biofilms:fungi:C. albicans. parasites L. mexicana (Molecules. 201
Evidence 15 Activity

Activity

MIC
Antiparasitic
3 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
Active against S. aureus ATCC 25923 (MIC 3 uM), E. faecalis ATCC 29212 (MIC 10 uM), B. megaterium (2 uM), Gram-negative E. coli ATCC 259
Evidence 16 Activity

Activity

MIC
Antiparasitic
10 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against S. aureus ATCC 25923 (MIC 3 uM), E. faecalis ATCC 29212 (MIC 10 uM), B. megaterium (2 uM), Gram-negative E. coli ATCC 25922 or ATCC 35218 (MIC 10 uM), P. aer
Evidence 17 Activity

Activity

MIC
Antiparasitic
10 µM

Target

Escherichia coli ATCC 25922 or ATCC 35218

Source & Reference

dbAMP 3.0 DRAMP

Other

25923 (MIC 3 uM), E. faecalis ATCC 29212 (MIC 10 uM), B. megaterium (2 uM), Gram-negative E. coli ATCC 25922 or ATCC 35218 (MIC 10 uM), P. aeruginosa ATCC 27853 (MIC 31 uM), fungi C. albicans ATCC 90028 (MIC 16 uM), C. parap
Evidence 18 Activity

Activity

MIC
Antiparasitic
31 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP 3.0 DRAMP

Other

10 uM), B. megaterium (2 uM), Gram-negative E. coli ATCC 25922 or ATCC 35218 (MIC 10 uM), P. aeruginosa ATCC 27853 (MIC 31 uM), fungi C. albicans ATCC 90028 (MIC 16 uM), C. parapsilosis ATCC 22019 (MIC 31 uM), and S.
Evidence 19 Activity

Activity

MIC
Antiparasitic
16 µM

Target

Candida albicans ATCC 90028

Source & Reference

dbAMP 3.0 DRAMP

Other

E. coli ATCC 25922 or ATCC 35218 (MIC 10 uM), P. aeruginosa ATCC 27853 (MIC 31 uM), fungi C. albicans ATCC 90028 (MIC 16 uM), C. parapsilosis ATCC 22019 (MIC 31 uM), and S. cerevisiae (MIC 8 uM). inhibited formatio
Evidence 20 Activity

Activity

MIC
Antiparasitic
31 µM

Target

C. parapsilosis ATCC 22019

Source & Reference

dbAMP 3.0 DRAMP

Other

C 10 uM), P. aeruginosa ATCC 27853 (MIC 31 uM), fungi C. albicans ATCC 90028 (MIC 16 uM), C. parapsilosis ATCC 22019 (MIC 31 uM), and S. cerevisiae (MIC 8 uM). inhibited formation of biofilms:fungi:C. albicans. parasit
Evidence 21 Activity

Activity

MIC
Antiparasitic
8 µM

Target

S. cerevisiae

Source & Reference

dbAMP 3.0 DRAMP

Other

M), fungi C. albicans ATCC 90028 (MIC 16 uM), C. parapsilosis ATCC 22019 (MIC 31 uM), and S. cerevisiae (MIC 8 uM). inhibited formation of biofilms:fungi:C. albicans. parasites L. mexicana (Molecules. 201
Evidence 22 Activity

Activity

MIC
Antiviral
3 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.
Active against S. aureus ATCC 25923 (MIC 3 uM), E. faecalis ATCC 29212 (MIC 10 uM), B. megaterium (2 uM), Gram-negative E. coli ATCC 259
Evidence 23 Activity

Activity

MIC
Antiviral
10 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Active against S. aureus ATCC 25923 (MIC 3 uM), E. faecalis ATCC 29212 (MIC 10 uM), B. megaterium (2 uM), Gram-negative E. coli ATCC 25922 or ATCC 35218 (MIC 10 uM), P. aer
Evidence 24 Activity

Activity

MIC
Antiviral
10 µM

Target

Escherichia coli ATCC 25922 or ATCC 35218

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

25923 (MIC 3 uM), E. faecalis ATCC 29212 (MIC 10 uM), B. megaterium (2 uM), Gram-negative E. coli ATCC 25922 or ATCC 35218 (MIC 10 uM), P. aeruginosa ATCC 27853 (MIC 31 uM), fungi C. albicans ATCC 90028 (MIC 16 uM), C. parap
Evidence 25 Activity

Activity

MIC
Antiviral
31 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

10 uM), B. megaterium (2 uM), Gram-negative E. coli ATCC 25922 or ATCC 35218 (MIC 10 uM), P. aeruginosa ATCC 27853 (MIC 31 uM), fungi C. albicans ATCC 90028 (MIC 16 uM), C. parapsilosis ATCC 22019 (MIC 31 uM), and S.
Evidence 26 Activity

Activity

MIC
Antiviral
16 µM

Target

Candida albicans ATCC 90028

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

E. coli ATCC 25922 or ATCC 35218 (MIC 10 uM), P. aeruginosa ATCC 27853 (MIC 31 uM), fungi C. albicans ATCC 90028 (MIC 16 uM), C. parapsilosis ATCC 22019 (MIC 31 uM), and S. cerevisiae (MIC 8 uM). inhibited formatio
Evidence 27 Activity

Activity

MIC
Antiviral
31 µM

Target

C. parapsilosis ATCC 22019

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

C 10 uM), P. aeruginosa ATCC 27853 (MIC 31 uM), fungi C. albicans ATCC 90028 (MIC 16 uM), C. parapsilosis ATCC 22019 (MIC 31 uM), and S. cerevisiae (MIC 8 uM). inhibited formation of biofilms:fungi:C. albicans. parasit
Evidence 28 Activity

Activity

MIC
Antiviral
8 µM

Target

S. cerevisiae

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

M), fungi C. albicans ATCC 90028 (MIC 16 uM), C. parapsilosis ATCC 22019 (MIC 31 uM), and S. cerevisiae (MIC 8 uM). inhibited formation of biofilms:fungi:C. albicans. parasites L. mexicana (Molecules. 201
Evidence 29 Activity

Activity

50% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
50% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Isolation, characterization and molecular cloning of new temporins from the skin of the North African ranid Pelophylax saharica. | Peptides | 2008
Evidence 30 Activity

Activity

50% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
50% Hemolysis | 25 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Analogues of temporin-SHa and uses thereof | Patent EP 2853538 A1 | 2015
Evidence 31 Activity

Activity

50% Cell death
Toxicity
>100 µM
Cytotoxic
50% Cell death | >100 | µM | target cell: Human fibroblasts

Target

Human fibroblasts

Source & Reference

NA
DBAASP
Analogues of temporin-SHa and uses thereof | Patent EP 2853538 A1 | 2015
Evidence 32 Activity

Activity

23% Cytotoxicity
Toxicity
20 µM
Cytotoxic
23% Cytotoxicity | 20 | µM | target cell: Human Primary Epidermal Keratinocytes (HEK)

Target

Human Primary Epidermal Keratinocytes (HEK)

Source & Reference

NA
DBAASP
Comparison of Anti-Viral Activity of Frog Skin Anti-Microbial Peptides Temporin-Sha and [K³]SHa to LL-37 and Temporin-Tb against Herpes Simplex Virus Type 1. | Viruses | 2019
Evidence 33 Activity

Activity

IC50
Toxicity
1558
Cytotoxic
Cytotoxicity: [Ref.31614561]Display cytotoxic against human gastric cells(N87 cell:IC50=1558 ± 324µM)

Source & Reference

NA
DRAMP
Biomolecules. 2019 Oct 11 9(10):598.
Evidence 34 Hemolysis

Source & Reference

APD_complete APD_hemolytic PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.