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Peptide record

TPDB06979

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB06979
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb APD_complete APD_hemolytic Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
ILGKIWEGIKSLF
Physicochemical Analysis
C74H118N16O17
ARNDCQHMPTYV
I
1503.85
9.88
2
1
7
+1
-0.88
0.777
150.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5500
365.73
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
1
E
0
Q
2
G
0
H
3
I
2
L
2
K
0
M
1
F
0
P
1
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 2 H: 0 I: 3 L: 2 K: 2 M: 0 F: 1 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
13
C74H118N16O17
1503.85
9.88
+1
-0.88
0.777
Evidence Records 35 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1-5 µg/mL

Target

Staphylococcus aureus ATCC 25293 or ATCC 6538

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram+ bacteria S. aureus ATCC 25293 or ATCC 6538 (MIC 1-5 ug/ml), clinical S. saprophyticus (MIC 1 ug/ml), B. subtillis CCT 2471 (MIC 10 ug/ml), B. thurin
Evidence 2 Activity

Activity

MIC
Antibacterial
1 µg/mL

Target

S. saprophyticus

Source & Reference

dbAMP DRAMP

Other

Active against Gram+ bacteria S. aureus ATCC 25293 or ATCC 6538 (MIC 1-5 ug/ml), clinical S. saprophyticus (MIC 1 ug/ml), B. subtillis CCT 2471 (MIC 10 ug/ml), B. thuringensis (MIC 25 ug/ml) S. epidermidis (MI
Evidence 3 Activity

Activity

MIC
Antibacterial
10 µg/mL

Target

B. subtillis CCT 2471

Source & Reference

dbAMP DRAMP

Other

aureus ATCC 25293 or ATCC 6538 (MIC 1-5 ug/ml), clinical S. saprophyticus (MIC 1 ug/ml), B. subtillis CCT 2471 (MIC 10 ug/ml), B. thuringensis (MIC 25 ug/ml) S. epidermidis (MIC 2 uM), Gram- bacteria P. aeroginosa
Evidence 4 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

B. thuringensis

Source & Reference

dbAMP DRAMP

Other

-5 ug/ml), clinical S. saprophyticus (MIC 1 ug/ml), B. subtillis CCT 2471 (MIC 10 ug/ml), B. thuringensis (MIC 25 ug/ml) S. epidermidis (MIC 2 uM), Gram- bacteria P. aeroginosa ATCC 27853 (MIC 100 uM), P.aerug
Evidence 5 Activity

Activity

MIC
Antibacterial
2 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP

Other

icus (MIC 1 ug/ml), B. subtillis CCT 2471 (MIC 10 ug/ml), B. thuringensis (MIC 25 ug/ml) S. epidermidis (MIC 2 uM), Gram- bacteria P. aeroginosa ATCC 27853 (MIC 100 uM), P.aeruginosa ATCC 15442 (MIC > 200
Evidence 6 Activity

Activity

MIC
Antibacterial
100 µM

Target

P. aeroginosa ATCC 27853

Source & Reference

dbAMP DRAMP

Other

(MIC 10 ug/ml), B. thuringensis (MIC 25 ug/ml) S. epidermidis (MIC 2 uM), Gram- bacteria P. aeroginosa ATCC 27853 (MIC 100 uM), P.aeruginosa ATCC 15442 (MIC > 200 ug/ml), E. coli CCT 1371 or ATCC 25922 (MIC 5-10 ug/m
Evidence 7 Activity

Activity

MIC
Antibacterial
5-10 µg/mL

Target

Escherichia coli CCT 1371 or ATCC 25922

Source & Reference

dbAMP DRAMP

Other

acteria P. aeroginosa ATCC 27853 (MIC 100 uM), P.aeruginosa ATCC 15442 (MIC > 200 ug/ml), E. coli CCT 1371 or ATCC 25922 (MIC 5-10 ug/ml) P.mirabilis (MIC > 200 ug/ml), S. typhimurium (MIC 2 uM).
Evidence 8 Activity

Activity

MIC
Antibacterial
2 µM

Target

S. typhimurium

Source & Reference

dbAMP DRAMP

Other

0 ug/ml), E. coli CCT 1371 or ATCC 25922 (MIC 5-10 ug/ml) P.mirabilis (MIC > 200 ug/ml), S. typhimurium (MIC 2 uM).
Evidence 9 Activity

Activity

MIC
Antifungal
1-5 µg/mL

Target

Staphylococcus aureus ATCC 25293 or ATCC 6538

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram+ bacteria S. aureus ATCC 25293 or ATCC 6538 (MIC 1-5 ug/ml), clinical S. saprophyticus (MIC 1 ug/ml), B. subtillis CCT 2471 (MIC 10 ug/ml), B. thurin
Evidence 10 Activity

Activity

MIC
Antifungal
1 µg/mL

Target

S. saprophyticus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against Gram+ bacteria S. aureus ATCC 25293 or ATCC 6538 (MIC 1-5 ug/ml), clinical S. saprophyticus (MIC 1 ug/ml), B. subtillis CCT 2471 (MIC 10 ug/ml), B. thuringensis (MIC 25 ug/ml) S. epidermidis (MI
Evidence 11 Activity

Activity

MIC
Antifungal
10 µg/mL

Target

B. subtillis CCT 2471

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

aureus ATCC 25293 or ATCC 6538 (MIC 1-5 ug/ml), clinical S. saprophyticus (MIC 1 ug/ml), B. subtillis CCT 2471 (MIC 10 ug/ml), B. thuringensis (MIC 25 ug/ml) S. epidermidis (MIC 2 uM), Gram- bacteria P. aeroginosa
Evidence 12 Activity

Activity

MIC
Antifungal
25 µg/mL

Target

B. thuringensis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

-5 ug/ml), clinical S. saprophyticus (MIC 1 ug/ml), B. subtillis CCT 2471 (MIC 10 ug/ml), B. thuringensis (MIC 25 ug/ml) S. epidermidis (MIC 2 uM), Gram- bacteria P. aeroginosa ATCC 27853 (MIC 100 uM), P.aerug
Evidence 13 Activity

Activity

MIC
Antifungal
2 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

icus (MIC 1 ug/ml), B. subtillis CCT 2471 (MIC 10 ug/ml), B. thuringensis (MIC 25 ug/ml) S. epidermidis (MIC 2 uM), Gram- bacteria P. aeroginosa ATCC 27853 (MIC 100 uM), P.aeruginosa ATCC 15442 (MIC > 200
Evidence 14 Activity

Activity

MIC
Antifungal
100 µM

Target

P. aeroginosa ATCC 27853

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

(MIC 10 ug/ml), B. thuringensis (MIC 25 ug/ml) S. epidermidis (MIC 2 uM), Gram- bacteria P. aeroginosa ATCC 27853 (MIC 100 uM), P.aeruginosa ATCC 15442 (MIC > 200 ug/ml), E. coli CCT 1371 or ATCC 25922 (MIC 5-10 ug/m
Evidence 15 Activity

Activity

MIC
Antifungal
5-10 µg/mL

Target

Escherichia coli CCT 1371 or ATCC 25922

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

acteria P. aeroginosa ATCC 27853 (MIC 100 uM), P.aeruginosa ATCC 15442 (MIC > 200 ug/ml), E. coli CCT 1371 or ATCC 25922 (MIC 5-10 ug/ml) P.mirabilis (MIC > 200 ug/ml), S. typhimurium (MIC 2 uM).
Evidence 16 Activity

Activity

MIC
Antifungal
2 µM

Target

S. typhimurium

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

0 ug/ml), E. coli CCT 1371 or ATCC 25922 (MIC 5-10 ug/ml) P.mirabilis (MIC > 200 ug/ml), S. typhimurium (MIC 2 uM).
Evidence 17 Activity

Activity

MIC
Antiparasitic
1-5 µg/mL

Target

Staphylococcus aureus ATCC 25293 or ATCC 6538

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against Gram+ bacteria S. aureus ATCC 25293 or ATCC 6538 (MIC 1-5 ug/ml), clinical S. saprophyticus (MIC 1 ug/ml), B. subtillis CCT 2471 (MIC 10 ug/ml), B. thurin
Evidence 18 Activity

Activity

MIC
Antiparasitic
1 µg/mL

Target

S. saprophyticus

Source & Reference

DRAMP

Other

Active against Gram+ bacteria S. aureus ATCC 25293 or ATCC 6538 (MIC 1-5 ug/ml), clinical S. saprophyticus (MIC 1 ug/ml), B. subtillis CCT 2471 (MIC 10 ug/ml), B. thuringensis (MIC 25 ug/ml) S. epidermidis (MI
Evidence 19 Activity

Activity

MIC
Antiparasitic
10 µg/mL

Target

B. subtillis CCT 2471

Source & Reference

DRAMP

Other

aureus ATCC 25293 or ATCC 6538 (MIC 1-5 ug/ml), clinical S. saprophyticus (MIC 1 ug/ml), B. subtillis CCT 2471 (MIC 10 ug/ml), B. thuringensis (MIC 25 ug/ml) S. epidermidis (MIC 2 uM), Gram- bacteria P. aeroginosa
Evidence 20 Activity

Activity

MIC
Antiparasitic
25 µg/mL

Target

B. thuringensis

Source & Reference

DRAMP

Other

-5 ug/ml), clinical S. saprophyticus (MIC 1 ug/ml), B. subtillis CCT 2471 (MIC 10 ug/ml), B. thuringensis (MIC 25 ug/ml) S. epidermidis (MIC 2 uM), Gram- bacteria P. aeroginosa ATCC 27853 (MIC 100 uM), P.aerug
Evidence 21 Activity

Activity

MIC
Antiparasitic
2 µM

Target

Staphylococcus epidermidis

Source & Reference

DRAMP

Other

icus (MIC 1 ug/ml), B. subtillis CCT 2471 (MIC 10 ug/ml), B. thuringensis (MIC 25 ug/ml) S. epidermidis (MIC 2 uM), Gram- bacteria P. aeroginosa ATCC 27853 (MIC 100 uM), P.aeruginosa ATCC 15442 (MIC > 200
Evidence 22 Activity

Activity

MIC
Antiparasitic
100 µM

Target

P. aeroginosa ATCC 27853

Source & Reference

DRAMP

Other

(MIC 10 ug/ml), B. thuringensis (MIC 25 ug/ml) S. epidermidis (MIC 2 uM), Gram- bacteria P. aeroginosa ATCC 27853 (MIC 100 uM), P.aeruginosa ATCC 15442 (MIC > 200 ug/ml), E. coli CCT 1371 or ATCC 25922 (MIC 5-10 ug/m
Evidence 23 Activity

Activity

MIC
Antiparasitic
5-10 µg/mL

Target

Escherichia coli CCT 1371 or ATCC 25922

Source & Reference

DRAMP

Other

acteria P. aeroginosa ATCC 27853 (MIC 100 uM), P.aeruginosa ATCC 15442 (MIC > 200 ug/ml), E. coli CCT 1371 or ATCC 25922 (MIC 5-10 ug/ml) P.mirabilis (MIC > 200 ug/ml), S. typhimurium (MIC 2 uM).
Evidence 24 Activity

Activity

MIC
Antiparasitic
2 µM

Target

S. typhimurium

Source & Reference

DRAMP

Other

0 ug/ml), E. coli CCT 1371 or ATCC 25922 (MIC 5-10 ug/ml) P.mirabilis (MIC > 200 ug/ml), S. typhimurium (MIC 2 uM).
Evidence 25 Activity

Activity

% Hemolysis
Hemolysis
2 96 %
[Ref.28657596] 2% hemolysis at 10 µg/ml, 96% hemolysis at 50 µg/ml against human red blood cells.

Target

human red blood cells

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Antibiotics (Basel). 2017 Jun 28 6(3). pii: E13.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 26 Activity

Activity

8% Hemolysis
Toxicity
10 µM
Hemolytic Cytotoxic
8% Hemolysis | 10 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antibiotic activity and structural analysis of the scorpion-derived antimicrobial peptide IsCT and its analogs. | Biochem Biophys Res Commun | 2004
Evidence 27 Activity

Activity

80% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
80% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence 28 Activity

Activity

0% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
0% Hemolysis | 25 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Purification, structure-function analysis, and molecular characterization of novel linear peptides from scorpion Opisthacanthus madagascariensis. | Biochem Biophys Res Commun | 2002
Evidence 29 Activity

Activity

10% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
10% Hemolysis | 100 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Purification, structure-function analysis, and molecular characterization of novel linear peptides from scorpion Opisthacanthus madagascariensis. | Biochem Biophys Res Commun | 2002
Evidence 30 Activity

Activity

95% Hemolysis
Toxicity
50-100 µg/mL
Hemolytic Cytotoxic
95% Hemolysis | 50-100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antibacterial Activity and Toxicity of Analogs of Scorpion Venom IsCT Peptides. | Antibiotics (Basel) | 2017
Evidence 31 Activity

Activity

50% Hemolysis
Toxicity
43.59 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 43.59 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
An unprecedented alteration in mode of action of IsCT resulting its translocation into bacterial cytoplasm and inhibition of macromolecular syntheses. | Sci Rep | 2015
Evidence 32 Activity

Activity

0% Hemolysis
Toxicity
6.25 µM
Hemolytic Cytotoxic
0% Hemolysis | 6.25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
IsCT-based Analogs Intending Better Biological Activity | J Pept Sci | 2019
Evidence 33 Activity

Activity

<5% Hemolysis
Toxicity
4 µM
Hemolytic Cytotoxic
<5% Hemolysis | 4 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Synthetic Peptide Derived from Scorpion Venom Displays Minimal Toxicity and Anti-infective Activity in an Animal Model. | ACS Infect Dis | 2021
Evidence 34 Activity

Activity

% Hemolysis
Toxicity
2 %
Hemolytic
Hemolytic_activity: [Ref.28657596] 2% hemolysis at 10 µg/ml, 96% hemolysis at 50 µg/ml against human red blood cells.

Target

erythrocytes

Source & Reference

NA
DRAMP
Antibiotics (Basel). 2017 Jun 28 6(3). pii: E13.
Evidence 35 Hemolysis

Activity

2 96 %
% Hemolysis
[Ref.28657596] 2% hemolysis at 10 µg/ml, 96% hemolysis at 50 µg/ml against human red blood cells.
Hemolysis

Target

human red blood cells

Source & Reference

APD_complete APD_hemolytic PD_Hemolysis
Antibiotics (Basel). 2017 Jun 28 6(3). pii: E13.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.