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Peptide record

TPDB06973

Antibacterial Toxicity standard

13 amino acids

3D PDB MODEL

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TPDB ID TPDB06973

Activity

Antibacterial Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 13-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.

Sequence

WKKILSKIKKLLK

FASTA

>TPDB06973|Antibacterial;Toxicity|length=13
WKKILSKIKKLLK

Formula C80H144N20O15

Absent Amino Acids ARNDCEQGHMFPTYV

Common Amino Acids K

Mass 1626.15

PI 11.21

Basic Residues 6

Acidic Residues 0

Hydrophobic Residues 6

Net Charge +6

Boman Index 1.92

Hydrophobicity -0.362

Aliphatic Index 150.00

Half Life

Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 5500

Absorbance 280nm 338.22

Polar Residues 1

number

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 3 K: 6 M: 0 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 0

Length

Formula

C80H144N20O15

Mass

1626.15

11.21

Net Charge

Boman Index

1.92

Hydrophobicity

-0.362

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.13 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source NA

Other

Evidence Text

active against Gram+ S. aureus (MIC 3.13 uM), E. faecalis (MIC 2.50 uM), E. faecium (MIC 1.56 uM), B. cereus (MIC 5.00 uM), S. epiderm

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2.50 µM

Target

Target Organism Enterococcus faecalis

Source & Reference

Database Source NA

Other

Evidence Text

active against Gram+ S. aureus (MIC 3.13 uM), E. faecalis (MIC 2.50 uM), E. faecium (MIC 1.56 uM), B. cereus (MIC 5.00 uM), S. epidermidis (MIC 3.13 uM), Gram- E

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.56 µM

Target

Target Organism E. faecium

Source & Reference

Database Source NA

Other

Evidence Text

active against Gram+ S. aureus (MIC 3.13 uM), E. faecalis (MIC 2.50 uM), E. faecium (MIC 1.56 uM), B. cereus (MIC 5.00 uM), S. epidermidis (MIC 3.13 uM), Gram- E. coli (MIC 3.13 uM), P. a

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 5.00 µM

Target

Target Organism B. cereus

Source & Reference

Database Source NA

Other

Evidence Text

ainst Gram+ S. aureus (MIC 3.13 uM), E. faecalis (MIC 2.50 uM), E. faecium (MIC 1.56 uM), B. cereus (MIC 5.00 uM), S. epidermidis (MIC 3.13 uM), Gram- E. coli (MIC 3.13 uM), P. aeruginosa including resis

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.13 µM

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source NA

Other

Evidence Text

C 3.13 uM), E. faecalis (MIC 2.50 uM), E. faecium (MIC 1.56 uM), B. cereus (MIC 5.00 uM), S. epidermidis (MIC 3.13 uM), Gram- E. coli (MIC 3.13 uM), P. aeruginosa including resistant MRPA0108 persisters (MIC

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.13 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source NA

Other

Evidence Text

), E. faecium (MIC 1.56 uM), B. cereus (MIC 5.00 uM), S. epidermidis (MIC 3.13 uM), Gram- E. coli (MIC 3.13 uM), P. aeruginosa including resistant MRPA0108 persisters (MIC 3.13-6.25 uM), K. pneumoniae

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.13-6.25 µM

Target

Target Organism Pseudomonas aeruginosa including resistant MRPA0108 persisters

Source & Reference

Database Source NA

Other

Evidence Text

uM), B. cereus (MIC 5.00 uM), S. epidermidis (MIC 3.13 uM), Gram- E. coli (MIC 3.13 uM), P. aeruginosa including resistant MRPA0108 persisters (MIC 3.13-6.25 uM), K. pneumoniae (MIC 25 uM), E. cloacae (MIC 12.5 uM), and P. mirabilis (MIC 6.25 uM).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µM

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source NA

Other

Evidence Text

(MIC 3.13 uM), P. aeruginosa including resistant MRPA0108 persisters (MIC 3.13-6.25 uM), K. pneumoniae (MIC 25 uM), E. cloacae (MIC 12.5 uM), and P. mirabilis (MIC 6.25 uM).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 12.5 µM

Target

Target Organism Enterobacter cloacae

Source & Reference

Database Source NA

Other

Evidence Text

sa including resistant MRPA0108 persisters (MIC 3.13-6.25 uM), K. pneumoniae (MIC 25 uM), E. cloacae (MIC 12.5 uM), and P. mirabilis (MIC 6.25 uM).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.25 µM

Target

Target Organism P. mirabilis

Source & Reference

Database Source NA

Other

Evidence Text

8 persisters (MIC 3.13-6.25 uM), K. pneumoniae (MIC 25 uM), E. cloacae (MIC 12.5 uM), and P. mirabilis (MIC 6.25 uM).

Evidence 11 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >500 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | >500 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Investigation of the role of tryptophan residues in cationic antimicrobial peptides to determine the mechanism of antimicrobial action. | J Appl Microbiol | 2013