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Peptide record

TPDB06962

Antibacterial Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB06962
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 13-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
HGVSGHGQHGTHG
Physicochemical Analysis
C51H74N22O17
ARNDCEILKMFPWY
G
1267.29
8.15
4
0
1
+0
4.81
-1.200
22.31
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
0
0.00
3
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
1
Q
5
G
4
H
0
I
0
L
0
K
0
M
0
F
0
P
1
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 5 H: 4 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 1 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
13
C51H74N22O17
1267.29
8.15
+0
4.81
-1.200
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
8-16 µg/mL

Target

Staphylococcus aureus ATCC25923 or penicillin-resistant

Source & Reference

NA

Other

active against Gram+ S. aureus ATCC25923 or penicillin-resistant (MIC 8-16 ug/ml), S. epidermidis penicillin-resistant (MIC 16 ug/ml), Gram- E. coli ATCC25922 or penicilli
Evidence 2 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

Staphylococcus epidermidis penicillin-resistant

Source & Reference

NA

Other

active against Gram+ S. aureus ATCC25923 or penicillin-resistant (MIC 8-16 ug/ml), S. epidermidis penicillin-resistant (MIC 16 ug/ml), Gram- E. coli ATCC25922 or penicillin-resistant (MIC 4-8 ug/ml), P. aeruginosa ATCC27853
Evidence 3 Activity

Activity

MIC
Antibacterial
4-8 µg/mL

Target

Escherichia coli ATCC25922 or penicillin-resistant

Source & Reference

NA

Other

lin-resistant (MIC 8-16 ug/ml), S. epidermidis penicillin-resistant (MIC 16 ug/ml), Gram- E. coli ATCC25922 or penicillin-resistant (MIC 4-8 ug/ml), P. aeruginosa ATCC27853 or penicillin-resistant (MIC 8-16 ug/ml), and K. pneumoniae ATCC
Evidence 4 Activity

Activity

MIC
Antibacterial
8-16 µg/mL

Target

Pseudomonas aeruginosa ATCC27853 or penicillin-resistant

Source & Reference

NA

Other

esistant (MIC 16 ug/ml), Gram- E. coli ATCC25922 or penicillin-resistant (MIC 4-8 ug/ml), P. aeruginosa ATCC27853 or penicillin-resistant (MIC 8-16 ug/ml), and K. pneumoniae ATCC13883 or penicillin-resistant (MIC 8 ug/ml).
Evidence 5 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

Klebsiella pneumoniae ATCC13883 or penicillin-resistant

Source & Reference

NA

Other

nt (MIC 4-8 ug/ml), P. aeruginosa ATCC27853 or penicillin-resistant (MIC 8-16 ug/ml), and K. pneumoniae ATCC13883 or penicillin-resistant (MIC 8 ug/ml).
Evidence 6 Activity

Activity

1% hemolysis
Toxicity
320 µg/mL
Hemolytic Cytotoxic
1% hemolysis | 320 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
ZL-2, a cathelicidin-derived antimicrobial peptide, has a broad antimicrobial activity against gram-positive bacteria and gram-negative bacteria in vitro and in vivo | Arch Pharm Res | 2015