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Peptide record

TPDB06959

Antibacterial Antifungal Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB06959
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb PD_Hemolysis
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLKALWNVAKSVF
Physicochemical Analysis
C76H115N17O16
RDCEQGHIMPTY
ALKFV
1522.85
10.60
2
0
9
+2
-2.90
0.938
120.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
5500
361.16
2
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
2
L
2
K
0
M
2
F
0
P
1
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 2 M: 0 F: 2 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
13
C76H115N17O16
1522.85
10.60
+2
-2.90
0.938
Evidence Records 5 records
Evidence 1 Activity

Activity

MHC
Hemolysis
1.60 µM
[Ref.27912176] MHC=1.60 µmol/L against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Eur J Med Chem. 2017 Jan 27 126:456-463.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

0% Hemolysis
Toxicity
1.6 µM
Hemolytic Cytotoxic
0% Hemolysis | 1.6 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Novel designed VmCT1 analogs with increased antimicrobial activity. | Eur J Med Chem | 2017
Evidence 3 Activity

Activity

37% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
37% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Novel designed VmCT1 analogs with increased antimicrobial activity. | Eur J Med Chem | 2017
Evidence 4 Activity

Activity

MHC
Toxicity
1.60 µm
Hemolytic
Hemolytic_activity: [Ref.27912176] MHC=1.60 µmol/L against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Eur J Med Chem. 2017 Jan 27 126:456-463.
Evidence 5 Hemolysis

Activity

1.60 µM
MHC
[Ref.27912176] MHC=1.60 µmol/L against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

PD_Hemolysis
Eur J Med Chem. 2017 Jan 27 126:456-463.
DRAMP4
PD_Hemolysis