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Peptide record

TPDB06944

Antibacterial Antifungal Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB06944
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FWGKLWEGVKNAI
Physicochemical Analysis
C76H110N18O17
RDCQHMPSTY
GKW
1547.82
9.88
2
1
7
+1
-1.36
-0.023
90.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
11000
710.68
1
Residue Composition
number
1
A
0
R
1
N
0
D
0
C
1
E
0
Q
2
G
0
H
1
I
1
L
2
K
0
M
1
F
0
P
0
S
0
T
2
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 2 H: 0 I: 1 L: 1 K: 2 M: 0 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 1
Chemical Descriptors
13
C76H110N18O17
1547.82
9.88
+1
-1.36
-0.023
Evidence Records 7 records
Evidence 1 Activity

Activity

MIC
Antibacterial
25-40 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against P. aeruginosa, and E. coli (MIC 25-40 uM). Weakest in this series of peptides.
Evidence 2 Activity

Activity

MIC
Antifungal
25-40 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against P. aeruginosa, and E. coli (MIC 25-40 uM). Weakest in this series of peptides.
Evidence 3 Activity

Activity

7% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
7% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of the venom from the Australian scorpion Urodacus yaschenkoi: Molecular mass analysis of components, cDNA sequences and peptides with antimicrobial activity. | Toxicon | 2013
Evidence 4 Activity

Activity

7% Hemolysis
Toxicity
40 µM
Hemolytic Cytotoxic
7% Hemolysis | 40 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of the venom from the Australian scorpion Urodacus yaschenkoi: Molecular mass analysis of components, cDNA sequences and peptides with antimicrobial activity. | Toxicon | 2013
Evidence 5 Activity

Activity

7% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
7% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of the venom from the Australian scorpion Urodacus yaschenkoi: Molecular mass analysis of components, cDNA sequences and peptides with antimicrobial activity. | Toxicon | 2013
Evidence 6 Activity

Activity

50% Hemolysis
Toxicity
>100 µM
Hemolytic Cytotoxic
50% Hemolysis | >100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Membrane interactions and biological activity of antimicrobial peptides from Australian scorpion. | Biochim Biophys Acta | 2014
Evidence 7 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.23182832]3% hemolytic activity at 12.5 µM, 6% hemolytic activity at 25 µM, 5% hemolytic activity at 50 µM, 35% hemolytic activity at 100 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Toxicon. 2013 Mar 1 63:44-54.