TPDB

3D PDB MODEL

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TPDB ID TPDB06943

Activity

Antibacterial Anticancer Antifungal Antiparasitic

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

FLPLLASLFSRLL

FASTA

>TPDB06943|Antibacterial;Anticancer;Antifungal;Antiparasitic|length=13
FLPLLASLFSRLL

Formula C74H120N16O16

Absent Amino Acids NDCEQGHIKMTWYV

Common Amino Acids L

Mass 1489.86

PI 11.05

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 9

Net Charge +1

Boman Index -4.27

Hydrophobicity 1.731

Aliphatic Index 187.69

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

1

A

1

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

6

L

0

K

0

M

2

F

1

P

2

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 6 K: 0 M: 0 F: 2 P: 1 S: 2 T: 0 W: 0 Y: 0 V: 0

Length

13

Formula

C74H120N16O16

Mass

1489.86

PI

11.05

Net Charge

+1

Boman Index

-4.27

Hydrophobicity

1.731

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 70 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Weak activity against E. coli (MIC 70 uM) but strong activity against S. aureus (MIC 2 uM).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Weak activity against E. coli (MIC 70 uM) but strong activity against S. aureus (MIC 2 uM).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 70 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Weak activity against E. coli (MIC 70 uM) but strong activity against S. aureus (MIC 2 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Weak activity against E. coli (MIC 70 uM) but strong activity against S. aureus (MIC 2 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 70 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Weak activity against E. coli (MIC 70 uM) but strong activity against S. aureus (MIC 2 uM).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source DRAMP

Other

Evidence Text

Weak activity against E. coli (MIC 70 uM) but strong activity against S. aureus (MIC 2 uM).