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Peptide record

TPDB06942

Antibacterial Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB06942
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 13-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
WKRIVRRIKRWLR
Physicochemical Analysis
C87H148N32O14
ANDCEQGHMFPSTY
R
1866.34
13.01
7
0
6
+7
1.22
-1.162
112.31
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
11000
589.39
0
Residue Composition
number
0
A
5
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
1
L
2
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 1 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 1
Chemical Descriptors
13
C87H148N32O14
1866.34
13.01
+7
1.22
-1.162
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>256 µM
Hemolytic Cytotoxic
50% Hemolysis | >256 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
LL-37-derived membrane-active FK-13 analogs possessing cell selectivity, anti-biofilm activity and synergy with chloramphenicol and anti-inflammatory activity. | Biochim Biophys Acta | 2017
Evidence 2 Activity

Activity

HC50
Toxicity
256 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.28161291] HC50>256 µM against human red blood cells | Cytotoxicity: [Ref.28161291] The cell viability of mouse macrophage RAW264.7 induced by FK13-a1 is 95.5%, 107.5%, 100.2%, 96.2%, 44.9% and 37.4% at peptide concentrations of 1.25, 2.5, 5, 10, 20 and 40 µM.## The cell viablity of human keratinocyte HaCaT induced by FK1

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta Biomembr. 2017 May 1859(5):722-733. doi: 10.1016/j.bbamem.2017.01.037.