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Peptide record

TPDB06926

Antibacterial Antiviral Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB06926
Antibacterial Antiviral Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AI4AVP dbAMP 3.0 DRAVP 2.0 HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Antiviral, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FIKRIARLLRKIF
Physicochemical Analysis
C81H140N24O14
NDCEQGHMPSTWYV
RI
1674.15
12.71
5
0
8
+5
-0.07
0.554
157.69
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
1
A
3
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
3
I
2
L
2
K
0
M
2
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 3 L: 2 K: 2 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C81H140N24O14
1674.15
12.71
+5
-0.07
0.554
Evidence Records 23 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6.25-25 µg/mL

Target

Escherichia coli AB94012 or ATCC 25922

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against Gram- E. coli AB94012 or ATCC 25922 (MIC 6.25-25 ug/ml), P. aeruginosa AB93066 or A092994 like 5 strains (MIC 25-100 ug/ml), Gram+ S. aureus AB94
Evidence 2 Activity

Activity

MIC
Antibacterial
25-100 µg/mL

Target

Pseudomonas aeruginosa AB93066 or A092994 like

Source & Reference

dbAMP DRAMP

Other

active against Gram- E. coli AB94012 or ATCC 25922 (MIC 6.25-25 ug/ml), P. aeruginosa AB93066 or A092994 like 5 strains (MIC 25-100 ug/ml), Gram+ S. aureus AB94004 or ATCC 25923 or MRSA (MIC 3.13 ug/ml), S. epidermidis (MIC 2.5-
Evidence 3 Activity

Activity

MIC
Antibacterial
3.13 µg/mL

Target

Staphylococcus aureus AB94004 or ATCC 25923 or MRSA

Source & Reference

dbAMP DRAMP

Other

6.25-25 ug/ml), P. aeruginosa AB93066 or A092994 like 5 strains (MIC 25-100 ug/ml), Gram+ S. aureus AB94004 or ATCC 25923 or MRSA (MIC 3.13 ug/ml), S. epidermidis (MIC 2.5-5.0 ug/ml), E. faecalis (MIC 5-10 ug/ml), E. faecium (MIC 5 ug/m
Evidence 4 Activity

Activity

MIC
Antibacterial
2.5-5.0 µg/mL

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP

Other

rains (MIC 25-100 ug/ml), Gram+ S. aureus AB94004 or ATCC 25923 or MRSA (MIC 3.13 ug/ml), S. epidermidis (MIC 2.5-5.0 ug/ml), E. faecalis (MIC 5-10 ug/ml), E. faecium (MIC 5 ug/ml), B. subtilis AB91021 (MIC 6.25 ug
Evidence 5 Activity

Activity

MIC
Antibacterial
5-10 µg/mL

Target

Enterococcus faecalis

Source & Reference

dbAMP DRAMP

Other

ureus AB94004 or ATCC 25923 or MRSA (MIC 3.13 ug/ml), S. epidermidis (MIC 2.5-5.0 ug/ml), E. faecalis (MIC 5-10 ug/ml), E. faecium (MIC 5 ug/ml), B. subtilis AB91021 (MIC 6.25 ug/ml), B. thuringiensis AB92037
Evidence 6 Activity

Activity

MIC
Antibacterial
5 µg/mL

Target

E. faecium

Source & Reference

dbAMP DRAMP

Other

MRSA (MIC 3.13 ug/ml), S. epidermidis (MIC 2.5-5.0 ug/ml), E. faecalis (MIC 5-10 ug/ml), E. faecium (MIC 5 ug/ml), B. subtilis AB91021 (MIC 6.25 ug/ml), B. thuringiensis AB92037 (MIC 6.25 ug/ml), and M.
Evidence 7 Activity

Activity

MIC
Antibacterial
6.25 µg/mL

Target

B. subtilis AB91021

Source & Reference

dbAMP DRAMP

Other

epidermidis (MIC 2.5-5.0 ug/ml), E. faecalis (MIC 5-10 ug/ml), E. faecium (MIC 5 ug/ml), B. subtilis AB91021 (MIC 6.25 ug/ml), B. thuringiensis AB92037 (MIC 6.25 ug/ml), and M. luteus AB93113 (MIC 6.25 ug/ml).
Evidence 8 Activity

Activity

MIC
Antibacterial
6.25 µg/mL

Target

B. thuringiensis AB92037

Source & Reference

dbAMP DRAMP

Other

aecalis (MIC 5-10 ug/ml), E. faecium (MIC 5 ug/ml), B. subtilis AB91021 (MIC 6.25 ug/ml), B. thuringiensis AB92037 (MIC 6.25 ug/ml), and M. luteus AB93113 (MIC 6.25 ug/ml).
Evidence 9 Activity

Activity

MIC
Antibacterial
6.25 µg/mL

Target

M. luteus AB93113

Source & Reference

dbAMP DRAMP

Other

ml), B. subtilis AB91021 (MIC 6.25 ug/ml), B. thuringiensis AB92037 (MIC 6.25 ug/ml), and M. luteus AB93113 (MIC 6.25 ug/ml).
Evidence 10 Activity

Activity

MIC
Antiviral
6.25-25 µg/mL

Target

Escherichia coli AB94012 or ATCC 25922

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.
active against Gram- E. coli AB94012 or ATCC 25922 (MIC 6.25-25 ug/ml), P. aeruginosa AB93066 or A092994 like 5 strains (MIC 25-100 ug/ml), Gram+ S. aureus AB94
Evidence 11 Activity

Activity

MIC
Antiviral
25-100 µg/mL

Target

Pseudomonas aeruginosa AB93066 or A092994 like

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

active against Gram- E. coli AB94012 or ATCC 25922 (MIC 6.25-25 ug/ml), P. aeruginosa AB93066 or A092994 like 5 strains (MIC 25-100 ug/ml), Gram+ S. aureus AB94004 or ATCC 25923 or MRSA (MIC 3.13 ug/ml), S. epidermidis (MIC 2.5-
Evidence 12 Activity

Activity

MIC
Antiviral
3.13 µg/mL

Target

Staphylococcus aureus AB94004 or ATCC 25923 or MRSA

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

6.25-25 ug/ml), P. aeruginosa AB93066 or A092994 like 5 strains (MIC 25-100 ug/ml), Gram+ S. aureus AB94004 or ATCC 25923 or MRSA (MIC 3.13 ug/ml), S. epidermidis (MIC 2.5-5.0 ug/ml), E. faecalis (MIC 5-10 ug/ml), E. faecium (MIC 5 ug/m
Evidence 13 Activity

Activity

MIC
Antiviral
2.5-5.0 µg/mL

Target

Staphylococcus epidermidis

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

rains (MIC 25-100 ug/ml), Gram+ S. aureus AB94004 or ATCC 25923 or MRSA (MIC 3.13 ug/ml), S. epidermidis (MIC 2.5-5.0 ug/ml), E. faecalis (MIC 5-10 ug/ml), E. faecium (MIC 5 ug/ml), B. subtilis AB91021 (MIC 6.25 ug
Evidence 14 Activity

Activity

MIC
Antiviral
5-10 µg/mL

Target

Enterococcus faecalis

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

ureus AB94004 or ATCC 25923 or MRSA (MIC 3.13 ug/ml), S. epidermidis (MIC 2.5-5.0 ug/ml), E. faecalis (MIC 5-10 ug/ml), E. faecium (MIC 5 ug/ml), B. subtilis AB91021 (MIC 6.25 ug/ml), B. thuringiensis AB92037
Evidence 15 Activity

Activity

MIC
Antiviral
5 µg/mL

Target

E. faecium

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

MRSA (MIC 3.13 ug/ml), S. epidermidis (MIC 2.5-5.0 ug/ml), E. faecalis (MIC 5-10 ug/ml), E. faecium (MIC 5 ug/ml), B. subtilis AB91021 (MIC 6.25 ug/ml), B. thuringiensis AB92037 (MIC 6.25 ug/ml), and M.
Evidence 16 Activity

Activity

MIC
Antiviral
6.25 µg/mL

Target

B. subtilis AB91021

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

epidermidis (MIC 2.5-5.0 ug/ml), E. faecalis (MIC 5-10 ug/ml), E. faecium (MIC 5 ug/ml), B. subtilis AB91021 (MIC 6.25 ug/ml), B. thuringiensis AB92037 (MIC 6.25 ug/ml), and M. luteus AB93113 (MIC 6.25 ug/ml).
Evidence 17 Activity

Activity

MIC
Antiviral
6.25 µg/mL

Target

B. thuringiensis AB92037

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

aecalis (MIC 5-10 ug/ml), E. faecium (MIC 5 ug/ml), B. subtilis AB91021 (MIC 6.25 ug/ml), B. thuringiensis AB92037 (MIC 6.25 ug/ml), and M. luteus AB93113 (MIC 6.25 ug/ml).
Evidence 18 Activity

Activity

MIC
Antiviral
6.25 µg/mL

Target

M. luteus AB93113

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

ml), B. subtilis AB91021 (MIC 6.25 ug/ml), B. thuringiensis AB92037 (MIC 6.25 ug/ml), and M. luteus AB93113 (MIC 6.25 ug/ml).
Evidence 19 Activity

Activity

50% Hemolysis
Toxicity
90.27 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 90.27 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antibacterial activity and mechanism of a scorpion venom peptide derivative in vitro and in vivo. | PLoS One | 2012
Evidence 20 Activity

Activity

6.9% Hemolysis
Toxicity
25 µg/mL
Hemolytic Cytotoxic
6.9% Hemolysis | 25 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Fine-Tuning of Alkaline Residues on the Hydrophilic Face Provides a Non-toxic Cationic α-Helical Antimicrobial Peptide Against Antibiotic-Resistant ESKAPE Pathogens. | Front Microbiol | 2021
Evidence 21 Activity

Activity

41% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
41% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Fine-Tuning of Alkaline Residues on the Hydrophilic Face Provides a Non-toxic Cationic α-Helical Antimicrobial Peptide Against Antibiotic-Resistant ESKAPE Pathogens. | Front Microbiol | 2021
Evidence 22 Activity

Activity

% Hemolysis
Toxicity
5 %
Hemolytic
Hemolytic_activity: [Ref.22792229]Non-hemolysis at 6.25 µg/ml, 5% hemolysis at 12.5 µg/ml,10% hemolysis at 25 µg/ml 15% hemolysis at 50 µg/ml, 40% hemolysis at 100 µg/ml against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
PLoS One. 2012 7(7):e40135. doi: 10.1371/journal.pone.0040135.
Evidence 23 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis