TPDB

3D PDB MODEL

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TPDB ID TPDB06924

Activity

Antibacterial Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 13-aa standard natural multi-activity (Antibacterial and Antifungal) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

YPELQQDLIARLL

FASTA

>TPDB06924|Antibacterial;Antifungal|length=13
YPELQQDLIARLL

Formula C72H118N18O21

Absent Amino Acids NCGHKMFSTWV

Common Amino Acids L

Mass 1571.84

PI 4.07

Basic Residues 1

Acidic Residues 2

Hydrophobic Residues 7

Net Charge -1

Boman Index 2.01

Hydrophobicity 0.008

Aliphatic Index 157.69

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 94.79

Polar Residues 3

number

1

A

1

R

0

N

1

D

0

C

1

E

2

Q

0

G

0

H

1

I

4

L

0

K

0

M

0

F

1

P

0

S

0

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 1 R: 1 N: 0 D: 1 C: 0 E: 1 Q: 2 G: 0 H: 0 I: 1 L: 4 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0

Length

13

Formula

C72H118N18O21

Mass

1571.84

PI

4.07

Net Charge

-1

Boman Index

2.01

Hydrophobicity

0.008

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50 µg/mL

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against E. coli ATCC25922 (MIC 50 ug/ml), S. aureus ATCC2592 (6.3 ug/ml), B. subtilis ATCC 6633 (3.1 ug/ml), and C. albicans ATCC2

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µg/mL

Target

Target Organism Candida albicans ATCC2002

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

22 (MIC 50 ug/ml), S. aureus ATCC2592 (6.3 ug/ml), B. subtilis ATCC 6633 (3.1 ug/ml), and C. albicans ATCC2002 (MIC 25 ug/ml). Updated 7/2021

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 50 µg/mL

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against E. coli ATCC25922 (MIC 50 ug/ml), S. aureus ATCC2592 (6.3 ug/ml), B. subtilis ATCC 6633 (3.1 ug/ml), and C. albicans ATCC2

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µg/mL

Target

Target Organism Candida albicans ATCC2002

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

22 (MIC 50 ug/ml), S. aureus ATCC2592 (6.3 ug/ml), B. subtilis ATCC 6633 (3.1 ug/ml), and C. albicans ATCC2002 (MIC 25 ug/ml). Updated 7/2021