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Peptide record

TPDB06922

Pantinin-2 Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB06922
Pantinin-2
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CancerPPD 2.0 AFP-GFuse Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
IFGAIWKGISSLL
Physicochemical Analysis
C69H109N15O16
RNDCEQHMPTYV
I
1404.72
10.10
1
0
8
+1
-3.93
1.423
157.69
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5500
391.54
2
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
3
I
2
L
1
K
0
M
1
F
0
P
2
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 3 L: 2 K: 1 M: 0 F: 1 P: 0 S: 2 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
13
C69H109N15O16
1404.72
10.10
+1
-3.93
1.423
Free
L
Linear
Free
Antimicrobial
Synthetic
Evidence Records 15 records
Evidence 1 Activity

Activity

MIC
Antibacterial
18-48 µM

Target

MRSA 16472

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
ve S. aureus AB 94004, B. magaterium AB 90008, M. luteus AB2010179, VRE S13 ( (anti-VRE), MRSA 16472 (MIC 18-48 uM), Gram-negative E. coli DH5alpha, S. enterica AB 2010185 (MIC 48-68 uM), and fungus C. tro
Evidence 2 Activity

Activity

MIC
Antibacterial
48-68 µM

Target

S. enterica AB 2010185

Source & Reference

dbAMP DRAMP

Other

2010179, VRE S13 ( (anti-VRE), MRSA 16472 (MIC 18-48 uM), Gram-negative E. coli DH5alpha, S. enterica AB 2010185 (MIC 48-68 uM), and fungus C. tropicalis AY 91009 (MIC 16 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
16 µM

Target

C. tropicalis AY 91009

Source & Reference

dbAMP DRAMP

Other

48 uM), Gram-negative E. coli DH5alpha, S. enterica AB 2010185 (MIC 48-68 uM), and fungus C. tropicalis AY 91009 (MIC 16 uM).
Evidence 4 Activity

Activity

IC50
IC50 = 12.5 ± 1.0 µM
Anticancer
12.5

Target

Breast Cancer
MDA-MB-231
Breast

Assay & Model

MTS assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2018

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 5 Activity

Activity

IC50
IC50 = 16.5 ± 1.0 µM
Anticancer
16.5

Target

Prostate Cancer
DU-145
Prostate

Assay & Model

MTS assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2018
Evidence 6 Activity

Activity

MIC
Antifungal
18-48 µM

Target

MRSA 16472

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
ve S. aureus AB 94004, B. magaterium AB 90008, M. luteus AB2010179, VRE S13 ( (anti-VRE), MRSA 16472 (MIC 18-48 uM), Gram-negative E. coli DH5alpha, S. enterica AB 2010185 (MIC 48-68 uM), and fungus C. tro
Evidence 7 Activity

Activity

MIC
Antifungal
48-68 µM

Target

S. enterica AB 2010185

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

2010179, VRE S13 ( (anti-VRE), MRSA 16472 (MIC 18-48 uM), Gram-negative E. coli DH5alpha, S. enterica AB 2010185 (MIC 48-68 uM), and fungus C. tropicalis AY 91009 (MIC 16 uM).
Evidence 8 Activity

Activity

MIC
Antifungal
16 µM

Target

C. tropicalis AY 91009

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

48 uM), Gram-negative E. coli DH5alpha, S. enterica AB 2010185 (MIC 48-68 uM), and fungus C. tropicalis AY 91009 (MIC 16 uM).
Evidence 9 Activity

Activity

% Hemolysis
Hemolysis
10 80 100 %
[Ref.23624072]10% hemolytic activity at 16 µM, 80% hemolytic activity at 32 µM, 100% hemolytic activity at 64 µM against human red bood cells

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Peptides 45:28-34(2013)##Peptides 51:35-45(2014

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 10 Activity

Activity

8% Hemolysis
Toxicity
16 µM
Hemolytic Cytotoxic
8% Hemolysis | 16 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Three new antimicrobial peptides from the scorpion Pandinus imperator. | Peptides | 2013
Evidence 11 Activity

Activity

81% Hemolysis
Toxicity
32 µM
Hemolytic Cytotoxic
81% Hemolysis | 32 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Three new antimicrobial peptides from the scorpion Pandinus imperator. | Peptides | 2013
Evidence 12 Activity

Activity

100% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
100% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Three new antimicrobial peptides from the scorpion Pandinus imperator. | Peptides | 2013
Evidence 13 Activity

Activity

IC50
Toxicity
43.5±2.0 µM
Cytotoxic
IC50 | 43.5±2.0 | µM | target cell: Human gingival fibroblasts

Target

Human gingival fibroblasts

Source & Reference

NA
DBAASP
Biophysical characterization and antitumor activity of synthetic Pantinin peptides from scorpion's venom | Biochim Biophys Acta | 2018
Evidence 14 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.23624072]10% hemolytic activity at 16 µM, 80% hemolytic activity at 32 µM, 100% hemolytic activity at 64 µM against human red bood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides 45:28-34(2013)##Peptides 51:35-45(2014
Evidence 15 Hemolysis

Activity

10 80 100 %
% Hemolysis
[Ref.23624072]10% hemolytic activity at 16 µM, 80% hemolytic activity at 32 µM, 100% hemolytic activity at 64 µM against human red bood cells
Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
Peptides 45:28-34(2013)##Peptides 51:35-45(2014
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.