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Peptide record

TPDB06911

Antibacterial Toxicity standard

12 amino acids

3D PDB MODEL

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TPDB ID TPDB06911

Activity

Antibacterial Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 12-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

RRLIRLWLRLLR

FASTA

>TPDB06911|Antibacterial;Toxicity|length=12
RRLIRLWLRLLR

Formula C77H138N28O13

Absent Amino Acids ANDCEQGHKMFPSTYV

Common Amino Acids RL

Mass 1664.12

PI 13.00

Basic Residues 5

Acidic Residues 0

Hydrophobic Residues 7

Net Charge +5

Boman Index -0.91

Hydrophobicity 0.008

Aliphatic Index 195.00

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 5500

Absorbance 280nm 330.50

Polar Residues 0

number

Amino Acid Distribution

A: 0 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 5 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0

Length

Formula

C77H138N28O13

Mass

1664.12

13.00

Net Charge

Boman Index

-0.91

Hydrophobicity

0.008

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µM

Target

Target Organism Escherichia coli BL21DE3

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

active against Gram- E. coli BL21DE3 (MIC 8 uM), P. aeruginosa ATCC27853 (MIC 4 uM), K. pneumoniae ATCC13883 (MIC 4 uM), S. enterica ATCC

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism Pseudomonas aeruginosa ATCC27853

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against Gram- E. coli BL21DE3 (MIC 8 uM), P. aeruginosa ATCC27853 (MIC 4 uM), K. pneumoniae ATCC13883 (MIC 4 uM), S. enterica ATCC14028 (MIC 8 uM), Gram+ B. subtilis

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism Klebsiella pneumoniae ATCC13883

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against Gram- E. coli BL21DE3 (MIC 8 uM), P. aeruginosa ATCC27853 (MIC 4 uM), K. pneumoniae ATCC13883 (MIC 4 uM), S. enterica ATCC14028 (MIC 8 uM), Gram+ B. subtilis (MIC 4 uM), S. aureus ATCC25923 (MIC

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µM

Target

Target Organism S. enterica ATCC14028

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

21DE3 (MIC 8 uM), P. aeruginosa ATCC27853 (MIC 4 uM), K. pneumoniae ATCC13883 (MIC 4 uM), S. enterica ATCC14028 (MIC 8 uM), Gram+ B. subtilis (MIC 4 uM), S. aureus ATCC25923 (MIC 4 uM), S. pyogenes ATCC19615 (MIC

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

3 (MIC 4 uM), K. pneumoniae ATCC13883 (MIC 4 uM), S. enterica ATCC14028 (MIC 8 uM), Gram+ B. subtilis (MIC 4 uM), S. aureus ATCC25923 (MIC 4 uM), S. pyogenes ATCC19615 (MIC 4 uM), E. feacalis ATCC29212

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism Staphylococcus aureus ATCC25923

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

iae ATCC13883 (MIC 4 uM), S. enterica ATCC14028 (MIC 8 uM), Gram+ B. subtilis (MIC 4 uM), S. aureus ATCC25923 (MIC 4 uM), S. pyogenes ATCC19615 (MIC 4 uM), E. feacalis ATCC29212 (MIC 4 uM).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism Streptococcus pyogenes ATCC19615

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

erica ATCC14028 (MIC 8 uM), Gram+ B. subtilis (MIC 4 uM), S. aureus ATCC25923 (MIC 4 uM), S. pyogenes ATCC19615 (MIC 4 uM), E. feacalis ATCC29212 (MIC 4 uM).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism E. feacalis ATCC29212

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

B. subtilis (MIC 4 uM), S. aureus ATCC25923 (MIC 4 uM), S. pyogenes ATCC19615 (MIC 4 uM), E. feacalis ATCC29212 (MIC 4 uM).

Evidence 9 Activity

Activity

Activity Endpoint >5% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 25 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

>5% Hemolysis | 25 | µM | target cell: Mouse erythrocytes

Target

Target Cell Mouse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Salt-resistant short antimicrobial peptides. | Biopolymers | 2016

Evidence 10 Activity

Activity

Activity Endpoint 5% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 50 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

5% Hemolysis | 50 | µM | target cell: Mouse erythrocytes

Target

Target Cell Mouse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Salt-resistant short antimicrobial peptides. | Biopolymers | 2016

Evidence 11 Activity

Activity

Activity Endpoint 18% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

18% Hemolysis | 100 | µM | target cell: Mouse erythrocytes

Target

Target Cell Mouse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Salt-resistant short antimicrobial peptides. | Biopolymers | 2016

Evidence 12 Activity

Activity

Activity Endpoint % Hemolysis

Detail Source Activity Toxicity

Activity Measurement 2 %

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.26795535] 2% hemolysis at 25 µM, 5% hemolysis at 50µM, 18% hemolysis at 100µM against mice red cells

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Biopolymers. 2016 May 106(3):345-56.