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Peptide record

TPDB06897

Antibacterial Antifungal Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB06897
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KLLSHSLLVTLA
Physicochemical Analysis
C60H107N15O16
RNDCEQGIMFPWY
L
1294.60
10.10
2
0
7
+1
-0.55
1.300
195.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
3
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
0
I
5
L
1
K
0
M
0
F
0
P
2
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 5 K: 1 M: 0 F: 0 P: 0 S: 2 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
12
C60H107N15O16
1294.60
10.10
+1
-0.55
1.300
Evidence Records 5 records
Evidence 1 Activity

Activity

4% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
4% Hemolysis | 100 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Potential of novel antimicrobial peptide P3 from bovine erythrocytes and its analogs to disrupt bacterial membranes in vitro and display activity against drug-resistant bacteria in a mouse model. | Antimicrob Agents Chemother | 2015
Evidence 2 Activity

Activity

5% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
5% Hemolysis | 200 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Potential of novel antimicrobial peptide P3 from bovine erythrocytes and its analogs to disrupt bacterial membranes in vitro and display activity against drug-resistant bacteria in a mouse model. | Antimicrob Agents Chemother | 2015
Evidence 3 Activity

Activity

10% Killing
Toxicity
100 µg/mL
Cytotoxic
10% Killing | 100 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Potential of novel antimicrobial peptide P3 from bovine erythrocytes and its analogs to disrupt bacterial membranes in vitro and display activity against drug-resistant bacteria in a mouse model. | Antimicrob Agents Chemother | 2015
Evidence 4 Activity

Activity

12% Killing
Toxicity
200 µg/mL
Cytotoxic
12% Killing | 200 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Potential of novel antimicrobial peptide P3 from bovine erythrocytes and its analogs to disrupt bacterial membranes in vitro and display activity against drug-resistant bacteria in a mouse model. | Antimicrob Agents Chemother | 2015
Evidence 5 Activity

Activity

% Hemolysis
Toxicity
2.5 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.25753638] 2.5% hemolysis at 50 µg/ml , 4% hemolysis at 100 µg/ml , 5% hemolysis at 200 µg/ml , 6% hemolysis at 300 µg/ml , 7% hemolysis at 400 µg/ml against human red blood cells | Cytotoxicity: [Ref.25753638] The cell viability of HaCaT cell lines is 88% and 85% at peptide concentrations of 200 and 400 µg/ml. In Kunming mice, the LD50 of JH-0 is 120 mg/kg for i.p. injection, while the LD50 of PMB(served as a control) is 50 mg/kg. No mortalit

Target

erythrocytes

Source & Reference

NA
DRAMP
Antimicrob Agents Chemother. 2015 May 59(5):2835-41. doi: 10.1128/AAC.04932-14.