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Peptide record

TPDB06886

Antibacterial Hemolysis Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB06886
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia PD_Hemolysis
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and PD_Hemolysis, with an available 3D structural model.
Sequence
GLLSLSLLGKLL
Physicochemical Analysis
C58H107N13O15
ARNDCEQHIMFPTWYV
L
1226.57
10.10
1
0
7
+1
-2.65
1.692
227.50
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
7
L
1
K
0
M
0
F
0
P
2
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 7 K: 1 M: 0 F: 0 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C58H107N13O15
1226.57
10.10
+1
-2.65
1.692
Evidence Records 4 records
Evidence 1 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Staphylococcus aureus USA300

Source & Reference

NA

Other

Active against S. aureus USA300 (MIC 12.5 uM), P-aeruginosa PAO1 (MIC > 25 uM), and E. coli ATCC 25922 (MIC 25 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
25 µM

Target

Escherichia coli ATCC 25922

Source & Reference

NA

Other

Active against S. aureus USA300 (MIC 12.5 uM), P-aeruginosa PAO1 (MIC > 25 uM), and E. coli ATCC 25922 (MIC 25 uM).
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
>50 µM
Hemolytic Cytotoxic
50% Hemolysis | >50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Low cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens. | Proc Natl Acad Sci U S A | 2019
Evidence 4 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis