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Peptide record

TPDB06882

Antibacterial Anticancer Antifungal Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB06882
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse CAFPdb dbAMP ToxinPred 3.0
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
FIFLPIFRRPVS
Physicochemical Analysis
C75H114N18O14
ANDCEQGHKMTWY
F
1491.84
12.40
2
0
7
+2
-1.85
1.033
121.67
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
1
L
0
K
0
M
3
F
2
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 1 K: 0 M: 0 F: 3 P: 2 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
12
C75H114N18O14
1491.84
12.40
+2
-1.85
1.033
Evidence Records 5 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against the fungus C. albicans. Granuliberin-SSa also showed activities that were almost equipotent to those of brevinin-2SSb against plant pathogens C. michiganensis subsp. michiganensis and P. oryzae. The peptide was also active against X. oryzae pv. oryzae at concentrations higher than 64 ug/mL. The peptide is toxic to mammalian cells (32 ug/ml, survival rates of COS7 and HepG2 (54.5% and 49.5%). Peptide sequence kindly provided by Prof. Iwamuro.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against the fungus C. albicans. Granuliberin-SSa also showed activities that were almost equipotent to those of brevinin-2SSb against plant pathogens C. michiganensis subsp. michiganensis and P. oryzae. The peptide was also active against X. oryzae pv. oryzae at concentrations higher than 64 ug/mL. The peptide is toxic to mammalian cells (32 ug/ml, survival rates of COS7 and HepG2 (54.5% and 49.5%). Peptide sequence kindly provided by Prof. Iwamuro.
Evidence 3 Activity

Activity

45.5% Killing
Toxicity
32 µg/mL
Cytotoxic
45.5% Killing | 32 | µg/mL | target cell: Monkey COS-7 cells

Target

Monkey COS-7 cells

Source & Reference

NA
DBAASP
Antimicrobial Property and Mode of Action of the Skin Peptides of the Sado Wrinkled Frog, Glandirana susurra, against Animal and Plant Pathogens. | Antibiotics (Basel) | 2020
Evidence 4 Activity

Activity

30% Killing
Toxicity
32 µg/mL
Cytotoxic
30% Killing | 32 | µg/mL | target cell: Calf pulmonary artery endothelium (CPAE)

Target

Calf pulmonary artery endothelium (CPAE)

Source & Reference

NA
DBAASP
Antimicrobial Property and Mode of Action of the Skin Peptides of the Sado Wrinkled Frog, Glandirana susurra, against Animal and Plant Pathogens. | Antibiotics (Basel) | 2020
Evidence 5 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: COS-7: 88.5% Killing=32µg/ml CPAE: 99.2% Killing=32µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
Antibiotics (Basel). 2020 Jul 29 9(8):457.