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Peptide record

TPDB06874

Antibacterial Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB06874
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 12-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
KWLKKWLKKWLK
Physicochemical Analysis
C87H137N21O13
ARNDCEQGHIMFPSTYV
K
1685.18
11.21
6
0
6
+6
-1.29
-1.225
97.50
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
16500
979.13
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
3
L
6
K
0
M
0
F
0
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 3 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
12
C87H137N21O13
1685.18
11.21
+6
-1.29
-1.225
Evidence Records 4 records
Evidence 1 Activity

Activity

50% Cytotoxicity
Toxicity
35 µM
Cytotoxic
50% Cytotoxicity | 35 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Cell-selectivity of tryptophan and tyrosine in amphiphilic ?-helical antimicrobial peptides against drug-resistant bacteria. | Biochem Biophys Res Commun | 2018
Evidence 2 Activity

Activity

76.5% Killing
Toxicity
100 µM
Cytotoxic
76.5% Killing | 100 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Cell-selectivity of tryptophan and tyrosine in amphiphilic ?-helical antimicrobial peptides against drug-resistant bacteria. | Biochem Biophys Res Commun | 2018
Evidence 3 Activity

Activity

47.3% Hemolysis
Toxicity
125 µM
Hemolytic Cytotoxic
47.3% Hemolysis | 125 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Cell-selectivity of tryptophan and tyrosine in amphiphilic ?-helical antimicrobial peptides against drug-resistant bacteria. | Biochem Biophys Res Commun | 2018
Evidence 4 Activity

Activity

65% Hemolysis
Toxicity
250 µM
Hemolytic Cytotoxic
65% Hemolysis | 250 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Cell-selectivity of tryptophan and tyrosine in amphiphilic ?-helical antimicrobial peptides against drug-resistant bacteria. | Biochem Biophys Res Commun | 2018