Back to search

Peptide record

TPDB06873

Antibacterial Anticancer Antifungal Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB06873
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GWWRRTVAKVRK
Physicochemical Analysis
C71H115N25O14
NDCEQHILMFPSY
R
1542.85
12.71
5
0
5
+5
0.83
-1.167
56.67
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11000
712.96
1
Residue Composition
number
1
A
3
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
1
T
2
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 1 W: 2 Y: 0 V: 2
Chemical Descriptors
12
C71H115N25O14
1542.85
12.71
+5
0.83
-1.167
Evidence Records 12 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.4 µM

Target

C. glutamicum ATCC 13032

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against C. glutamicum ATCC 13032 (MIC 0.4 uM), S.aureus ATCC 9144 (MIC 12.5 uM), P. aeruginosa ATCC 27853 (MIC 1.6 uM), and E. coli ATC
Evidence 2 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

S.aureus ATCC 9144

Source & Reference

dbAMP

Other

Active against C. glutamicum ATCC 13032 (MIC 0.4 uM), S.aureus ATCC 9144 (MIC 12.5 uM), P. aeruginosa ATCC 27853 (MIC 1.6 uM), and E. coli ATCC 25922 (MIC 3.1 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
1.6 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP

Other

Active against C. glutamicum ATCC 13032 (MIC 0.4 uM), S.aureus ATCC 9144 (MIC 12.5 uM), P. aeruginosa ATCC 27853 (MIC 1.6 uM), and E. coli ATCC 25922 (MIC 3.1 uM).
Evidence 4 Activity

Activity

MIC
Antibacterial
3.1 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP

Other

MIC 0.4 uM), S.aureus ATCC 9144 (MIC 12.5 uM), P. aeruginosa ATCC 27853 (MIC 1.6 uM), and E. coli ATCC 25922 (MIC 3.1 uM).
Evidence 5 Activity

Activity

MIC
Antifungal
0.4 µM

Target

C. glutamicum ATCC 13032

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against C. glutamicum ATCC 13032 (MIC 0.4 uM), S.aureus ATCC 9144 (MIC 12.5 uM), P. aeruginosa ATCC 27853 (MIC 1.6 uM), and E. coli ATC
Evidence 6 Activity

Activity

MIC
Antifungal
12.5 µM

Target

S.aureus ATCC 9144

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against C. glutamicum ATCC 13032 (MIC 0.4 uM), S.aureus ATCC 9144 (MIC 12.5 uM), P. aeruginosa ATCC 27853 (MIC 1.6 uM), and E. coli ATCC 25922 (MIC 3.1 uM).
Evidence 7 Activity

Activity

MIC
Antifungal
1.6 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against C. glutamicum ATCC 13032 (MIC 0.4 uM), S.aureus ATCC 9144 (MIC 12.5 uM), P. aeruginosa ATCC 27853 (MIC 1.6 uM), and E. coli ATCC 25922 (MIC 3.1 uM).
Evidence 8 Activity

Activity

MIC
Antifungal
3.1 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP CAFPdb Antifungipept

Other

MIC 0.4 uM), S.aureus ATCC 9144 (MIC 12.5 uM), P. aeruginosa ATCC 27853 (MIC 1.6 uM), and E. coli ATCC 25922 (MIC 3.1 uM).
Evidence 9 Activity

Activity

2.4% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
2.4% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity Relationship Studies of Shortened Analogues of the Antimicrobial Peptide EeCentrocin 1 From the Sea Urchin Echinus Esculentus. | J Pept Sci | 2019
Evidence 10 Activity

Activity

25.1% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
25.1% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity Relationship Studies of Shortened Analogues of the Antimicrobial Peptide EeCentrocin 1 From the Sea Urchin Echinus Esculentus. | J Pept Sci | 2019
Evidence 11 Activity

Activity

IC50
Toxicity
>200 µM
Cytotoxic
IC50 | >200 | µM | target cell: Human fibroblasts MRC-5

Target

Human fibroblasts MRC-5

Source & Reference

NA
DBAASP
Structure-activity Relationship Studies of Shortened Analogues of the Antimicrobial Peptide EeCentrocin 1 From the Sea Urchin Echinus Esculentus. | J Pept Sci | 2019
Evidence 12 Activity

Activity

IC50
Toxicity
200 µM
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes:2.4% Hemolysis=25 µM 25.1% Hemolysis=200 µM | Cytotoxicity: MRC-5: IC50>200 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
J Pept Sci. 2020 Feb 26(2):e3233