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Peptide record

TPDB06868

Antibacterial Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB06868
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 12-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
KWKKLLKKPLLK
Physicochemical Analysis
C76H135N19O13
ARNDCEQGHIMFSTYV
K
1523.03
11.21
6
0
5
+6
2.30
-0.892
130.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
361.12
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
4
L
6
K
0
M
0
F
1
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 4 K: 6 M: 0 F: 0 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
12
C76H135N19O13
1523.03
11.21
+6
2.30
-0.892
Evidence Records 3 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.13 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

NA

Other

nst Gram- P-aeruginosa ATCC 27853 (MIC >25 uM), A-baumannii KCTC 2508 (MIC >25 uM), Gram+ S. aureus ATCC 25923 (MIC 3.13 uM), and B. subtilis KCTC 2217 (MIC 6.25 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

B. subtilis KCTC 2217

Source & Reference

NA

Other

25 uM), A-baumannii KCTC 2508 (MIC >25 uM), Gram+ S. aureus ATCC 25923 (MIC 3.13 uM), and B. subtilis KCTC 2217 (MIC 6.25 uM).
Evidence 3 Activity

Activity

0% Killing
Toxicity
100 µM
Cytotoxic
0% Killing | 100 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Mechanism of action of antimicrobial peptide P5 truncations against Pseudomonas aeruginosa and Staphylococcus aureus | AMB Express | 2019