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Peptide record

TPDB06833

Antibacterial Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB06833
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 12-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
GIGKFLKKAKKF
Physicochemical Analysis
C67H113N17O13
RNDCEQHMPSTWYV
K
1364.74
11.12
5
0
5
+5
1.67
-0.383
73.33
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
1
I
1
L
5
K
0
M
2
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 1 K: 5 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C67H113N17O13
1364.74
11.12
+5
1.67
-0.383
Evidence Records 3 records
Evidence 1 Activity

Activity

MIC
Antibacterial
32-64 µg/mL

Target

Staphylococcus epidermidis ATCC 35984

Source & Reference

NA

Other

against S.aureus ATCC 25923 or ATCC 33591 MRSA (MIC 512 ug/ml or greater, MRSA-inactive), S. epidermidis ATCC 35984 (MIC 32-64 ug/ml), and P. aeruginosa ATCC 27853 (MIC 4-8 ug/ml).
Evidence 2 Activity

Activity

MIC
Antibacterial
4-8 µg/mL

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

NA

Other

IC 512 ug/ml or greater, MRSA-inactive), S. epidermidis ATCC 35984 (MIC 32-64 ug/ml), and P. aeruginosa ATCC 27853 (MIC 4-8 ug/ml).
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial properties of membrane-active dodecapeptides derived from MSI-78. | Biochim Biophys Acta | 2015