Back to search

Peptide record

TPDB06827

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB06827
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLLSGTSVRGSI
Physicochemical Analysis
C48H87N15O17
ANDCEQHKMFPWY
GS
1146.31
11.05
1
0
4
+1
0.01
0.625
121.67
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
4
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
3
G
0
H
1
I
2
L
0
K
0
M
0
F
0
P
3
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 1 L: 2 K: 0 M: 0 F: 0 P: 0 S: 3 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
12
C48H87N15O17
1146.31
11.05
+1
0.01
0.625
Evidence Records 21 records
Evidence 1 Activity

Activity

MIC
Antibacterial
36 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against E. coli (MIC 36 ug/ml), S. aureus (MIC 18 ug/ml), B. subtilis (MIC 18 ug/ml), and C. albicans (MIC 9 ug/ml).
Evidence 2 Activity

Activity

MIC
Antibacterial
18 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

active against E. coli (MIC 36 ug/ml), S. aureus (MIC 18 ug/ml), B. subtilis (MIC 18 ug/ml), and C. albicans (MIC 9 ug/ml).
Evidence 3 Activity

Activity

MIC
Antibacterial
18 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

active against E. coli (MIC 36 ug/ml), S. aureus (MIC 18 ug/ml), B. subtilis (MIC 18 ug/ml), and C. albicans (MIC 9 ug/ml).
Evidence 4 Activity

Activity

MIC
Antibacterial
9 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

against E. coli (MIC 36 ug/ml), S. aureus (MIC 18 ug/ml), B. subtilis (MIC 18 ug/ml), and C. albicans (MIC 9 ug/ml).
Evidence 5 Activity

Activity

MIC
Antifungal
36 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
active against E. coli (MIC 36 ug/ml), S. aureus (MIC 18 ug/ml), B. subtilis (MIC 18 ug/ml), and C. albicans (MIC 9 ug/ml).
Evidence 6 Activity

Activity

MIC
Antifungal
18 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

active against E. coli (MIC 36 ug/ml), S. aureus (MIC 18 ug/ml), B. subtilis (MIC 18 ug/ml), and C. albicans (MIC 9 ug/ml).
Evidence 7 Activity

Activity

MIC
Antifungal
18 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

active against E. coli (MIC 36 ug/ml), S. aureus (MIC 18 ug/ml), B. subtilis (MIC 18 ug/ml), and C. albicans (MIC 9 ug/ml).
Evidence 8 Activity

Activity

MIC
Antifungal
9 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

against E. coli (MIC 36 ug/ml), S. aureus (MIC 18 ug/ml), B. subtilis (MIC 18 ug/ml), and C. albicans (MIC 9 ug/ml).
Evidence 9 Activity

Activity

MIC
Antiparasitic
36 µg/mL

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
active against E. coli (MIC 36 ug/ml), S. aureus (MIC 18 ug/ml), B. subtilis (MIC 18 ug/ml), and C. albicans (MIC 9 ug/ml).
Evidence 10 Activity

Activity

MIC
Antiparasitic
18 µg/mL

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

active against E. coli (MIC 36 ug/ml), S. aureus (MIC 18 ug/ml), B. subtilis (MIC 18 ug/ml), and C. albicans (MIC 9 ug/ml).
Evidence 11 Activity

Activity

MIC
Antiparasitic
18 µg/mL

Target

B. subtilis

Source & Reference

DRAMP

Other

active against E. coli (MIC 36 ug/ml), S. aureus (MIC 18 ug/ml), B. subtilis (MIC 18 ug/ml), and C. albicans (MIC 9 ug/ml).
Evidence 12 Activity

Activity

MIC
Antiparasitic
9 µg/mL

Target

Candida albicans

Source & Reference

DRAMP

Other

against E. coli (MIC 36 ug/ml), S. aureus (MIC 18 ug/ml), B. subtilis (MIC 18 ug/ml), and C. albicans (MIC 9 ug/ml).
Evidence 13 Activity

Activity

MIC
Antiviral
36 µg/mL

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
active against E. coli (MIC 36 ug/ml), S. aureus (MIC 18 ug/ml), B. subtilis (MIC 18 ug/ml), and C. albicans (MIC 9 ug/ml).
Evidence 14 Activity

Activity

MIC
Antiviral
18 µg/mL

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

active against E. coli (MIC 36 ug/ml), S. aureus (MIC 18 ug/ml), B. subtilis (MIC 18 ug/ml), and C. albicans (MIC 9 ug/ml).
Evidence 15 Activity

Activity

MIC
Antiviral
18 µg/mL

Target

B. subtilis

Source & Reference

DRAMP

Other

active against E. coli (MIC 36 ug/ml), S. aureus (MIC 18 ug/ml), B. subtilis (MIC 18 ug/ml), and C. albicans (MIC 9 ug/ml).
Evidence 16 Activity

Activity

MIC
Antiviral
9 µg/mL

Target

Candida albicans

Source & Reference

DRAMP

Other

against E. coli (MIC 36 ug/ml), S. aureus (MIC 18 ug/ml), B. subtilis (MIC 18 ug/ml), and C. albicans (MIC 9 ug/ml).
Evidence 17 Activity

Activity

% Hemolysis
Hemolysis
4.7 %
[Ref.17272268] RCH=23.9 ± 4.7% against rabbit red blood cells. RCH, red cell hemolysis.

Target

rabbit red blood cells

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Mol Cell Proteomics. 2007 May 6(5):882-894.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 18 Activity

Activity

24% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
24% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Anti-infection peptidomics of amphibian skin. | Mol Cell Proteomics | 2007
Evidence 19 Activity

Activity

(15.5±7.3)% degranulation
Toxicity
50 µg/mL
Cytotoxic
(15.5±7.3)% degranulation | 50 | µg/mL | target cell: Human mast cells

Target

Human mast cells

Source & Reference

NA
DBAASP
Anti-infection peptidomics of amphibian skin. | Mol Cell Proteomics | 2007
Evidence 20 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.17272268] RCH=23.9 ± 4.7% against rabbit red blood cells. RCH, red cell hemolysis.

Target

erythrocytes

Source & Reference

NA
DRAMP
Mol Cell Proteomics. 2007 May 6(5):882-894.
Evidence 21 Hemolysis

Activity

4.7 %
% Hemolysis
[Ref.17272268] RCH=23.9 ± 4.7% against rabbit red blood cells. RCH, red cell hemolysis.
Hemolysis

Target

rabbit red blood cells

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
Mol Cell Proteomics. 2007 May 6(5):882-894.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.