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Peptide record

TPDB06823

Halictine 2 Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB06823
Halictine 2
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab AFP-GFuse Antifungipept CAFPdb APD_complete APD_hemolytic Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GKWMSLLKHILK
Physicochemical Analysis
C69H116N18O14S1
ARNDCEQFPTYV
LK
1453.85
10.84
4
0
6
+3
-0.00
0.067
130.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
378.31
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
1
H
1
I
3
L
3
K
1
M
0
F
0
P
1
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 1 L: 3 K: 3 M: 1 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
12
C69H116N18O14S1
1453.85
10.84
+3
-0.00
0.067
Free
L
Not Available
Free
Anticancer
Venom, the eusocial bee, Halictus sexcinctus
Evidence Records 16 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.8-7.7 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Highly active against B. subtilis, S. aureus, E. coli (MIC 0.8-7.7 uM) and moderately active against P. aeruginosa (MIC ~45 uM). Also active against C. albicans
Evidence 2 Activity

Activity

MIC
Antibacterial
6-7 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

0.8-7.7 uM) and moderately active against P. aeruginosa (MIC ~45 uM). Also active against C. albicans (MIC 6-7 uM) as well as cancer cells such as Hela S3, CRC SW480, and CCRF-CEMT IC50 12-35 uM (Slaninov
Evidence 3 Activity

Activity

Not Available
Anticancer

Target

Not Available
Not Available
Not Available

Assay & Model

Not Available
Not Available

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2010

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 4 Activity

Activity

MIC
Antifungal
0.8-7.7 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Highly active against B. subtilis, S. aureus, E. coli (MIC 0.8-7.7 uM) and moderately active against P. aeruginosa (MIC ~45 uM). Also active against C. albicans
Evidence 5 Activity

Activity

MIC
Antifungal
6-7 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

0.8-7.7 uM) and moderately active against P. aeruginosa (MIC ~45 uM). Also active against C. albicans (MIC 6-7 uM) as well as cancer cells such as Hela S3, CRC SW480, and CCRF-CEMT IC50 12-35 uM (Slaninov
Evidence 6 Activity

Activity

MIC
Antiparasitic
0.8-7.7 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Highly active against B. subtilis, S. aureus, E. coli (MIC 0.8-7.7 uM) and moderately active against P. aeruginosa (MIC ~45 uM). Also active against C. albicans
Evidence 7 Activity

Activity

MIC
Antiparasitic
6-7 µM

Target

Candida albicans

Source & Reference

DRAMP

Other

0.8-7.7 uM) and moderately active against P. aeruginosa (MIC ~45 uM). Also active against C. albicans (MIC 6-7 uM) as well as cancer cells such as Hela S3, CRC SW480, and CCRF-CEMT IC50 12-35 uM (Slaninov
Evidence 8 Activity

Activity

MIC
Antiviral
0.8-7.7 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Highly active against B. subtilis, S. aureus, E. coli (MIC 0.8-7.7 uM) and moderately active against P. aeruginosa (MIC ~45 uM). Also active against C. albicans
Evidence 9 Activity

Activity

MIC
Antiviral
6-7 µM

Target

Candida albicans

Source & Reference

DRAMP

Other

0.8-7.7 uM) and moderately active against P. aeruginosa (MIC ~45 uM). Also active against C. albicans (MIC 6-7 uM) as well as cancer cells such as Hela S3, CRC SW480, and CCRF-CEMT IC50 12-35 uM (Slaninov
Evidence 10 Activity

Activity

LC50
Hemolysis
78.1 µM
[Ref.20198492] LC50=78.1µM against rat red blood cells

Target

rat red blood cells

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Amino Acids. 2010 Aug 39(3):763-75.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 11 Activity

Activity

50% Hemolysis
Toxicity
78.1 µM
Hemolytic Cytotoxic
50% Hemolysis | 78.1 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Evidence 12 Activity

Activity

IC50
Toxicity
23±9 µM
Cytotoxic
IC50 | 23±9 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells. | Peptides | 2012
Evidence 13 Activity

Activity

IC50
Toxicity
40±5 µM
Cytotoxic
IC50 | 40±5 | µM | target cell: Rat epithelial cells IEC-6, CRL-1592

Target

Rat epithelial cells IEC-6, CRL-1592

Source & Reference

NA
DBAASP
Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells. | Peptides | 2012
Evidence 14 Activity

Activity

50% Hemolysis
Toxicity
78 µM
Hemolytic Cytotoxic
50% Hemolysis | 78 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antifungal activity of analogues of antimicrobial peptides isolated from bee venoms against vulvovaginal Candida spp. | FEMS Yeast Res | 2019
Evidence 15 Activity

Activity

LC50
Toxicity
78.1 µM
Hemolytic
Hemolytic_activity: [Ref.20198492] LC50=78.1µM against rat red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Amino Acids. 2010 Aug 39(3):763-75.
Evidence 16 Hemolysis

Activity

78.1 µM
LC50
[Ref.20198492] LC50=78.1µM against rat red blood cells
Hemolysis

Target

rat red blood cells

Source & Reference

APD_complete APD_hemolytic PD_Hemolysis
Amino Acids. 2010 Aug 39(3):763-75.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.