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Peptide record

TPDB06817

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard

12 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB06817

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP pep-lab Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 12-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

RLCRIVVIRVCR

FASTA

>TPDB06817|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Hemolysis;Toxicity|length=12
RLCRIVVIRVCR

Formula C63H120N24O13S2

Absent Amino Acids ANDEQGHKMFPSTWY

Common Amino Acids R

Mass 1485.92

PI 11.93

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 6

Net Charge +4

Boman Index 1.79

Hydrophobicity 1.033

Aliphatic Index 170.00

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 125

Absorbance 280nm 8.41

Polar Residues 2

number

Amino Acid Distribution

A: 0 R: 4 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 3

Length

Formula

C63H120N24O13S2

Mass

1485.92

11.93

Net Charge

Boman Index

1.79

Hydrophobicity

1.033

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 11 µM

Target

Target Organism B. megatherium Bml 1

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against B. megatherium Bml 1 (MIC 11 uM), B. subtilis Bs11 (MIC 17 uM), and M. luteus Mill (MIC 20 uM) (provided by Chunfeng Wang)

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 17 µM

Target

Target Organism B. subtilis Bs11

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against B. megatherium Bml 1 (MIC 11 uM), B. subtilis Bs11 (MIC 17 uM), and M. luteus Mill (MIC 20 uM) (provided by Chunfeng Wang).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 20 µM

Target

Target Organism M. luteus Mill

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against B. megatherium Bml 1 (MIC 11 uM), B. subtilis Bs11 (MIC 17 uM), and M. luteus Mill (MIC 20 uM) (provided by Chunfeng Wang).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 11 µM

Target

Target Organism B. megatherium Bml 1

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against B. megatherium Bml 1 (MIC 11 uM), B. subtilis Bs11 (MIC 17 uM), and M. luteus Mill (MIC 20 uM) (provided by Chunfeng Wang)

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 17 µM

Target

Target Organism B. subtilis Bs11

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Active against B. megatherium Bml 1 (MIC 11 uM), B. subtilis Bs11 (MIC 17 uM), and M. luteus Mill (MIC 20 uM) (provided by Chunfeng Wang).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 20 µM

Target

Target Organism M. luteus Mill

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Active against B. megatherium Bml 1 (MIC 11 uM), B. subtilis Bs11 (MIC 17 uM), and M. luteus Mill (MIC 20 uM) (provided by Chunfeng Wang).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 11 µM

Target

Target Organism B. megatherium Bml 1

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against B. megatherium Bml 1 (MIC 11 uM), B. subtilis Bs11 (MIC 17 uM), and M. luteus Mill (MIC 20 uM) (provided by Chunfeng Wang)

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 17 µM

Target

Target Organism B. subtilis Bs11

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against B. megatherium Bml 1 (MIC 11 uM), B. subtilis Bs11 (MIC 17 uM), and M. luteus Mill (MIC 20 uM) (provided by Chunfeng Wang).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 20 µM

Target

Target Organism M. luteus Mill

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against B. megatherium Bml 1 (MIC 11 uM), B. subtilis Bs11 (MIC 17 uM), and M. luteus Mill (MIC 20 uM) (provided by Chunfeng Wang).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 11 µM

Target

Target Organism B. megatherium Bml 1

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets.

Evidence Text

Active against B. megatherium Bml 1 (MIC 11 uM), B. subtilis Bs11 (MIC 17 uM), and M. luteus Mill (MIC 20 uM) (provided by Chunfeng Wang)

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 17 µM

Target

Target Organism B. subtilis Bs11

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against B. megatherium Bml 1 (MIC 11 uM), B. subtilis Bs11 (MIC 17 uM), and M. luteus Mill (MIC 20 uM) (provided by Chunfeng Wang).

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 20 µM

Target

Target Organism M. luteus Mill

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against B. megatherium Bml 1 (MIC 11 uM), B. subtilis Bs11 (MIC 17 uM), and M. luteus Mill (MIC 20 uM) (provided by Chunfeng Wang).

Evidence 13 Activity

Activity

Activity Endpoint MHC

Detail Source Activity Toxicity

Activity Measurement 64 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

MHC | 64 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Improved derivatives of bactenecin, a cyclic dodecameric antimicrobial cationic peptide. | Antimicrob Agents Chemother | 1999

Evidence 14 Activity

Activity

Activity Endpoint 0% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

0% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Salt-resistant homodimeric bactenecin, a cathelicidin-derived antimicrobial peptide. | FEBS J | 2008

Evidence 15 Activity

Activity

Activity Endpoint 1.3% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

1.3% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

A significantly enhanced antibacterial spectrum of D-enantiomeric lipopeptide bactenecin. | Biochem Biophys Res Commun | 2019

Evidence 16 Activity

Activity

Activity Endpoint <10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 400 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

<10% Hemolysis | 400 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Linear bactenecin analogs with cell selectivity and anti-endotoxic activity. | J Pept Sci | 2012

Evidence 17 Activity

Activity

Activity Endpoint 5% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 64 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

5% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Characterization of the Bioactivity and Mechanism of Bactenecin Derivatives Against Food-Pathogens. | Front Microbiol | 2019

Evidence 18 Activity

Activity

Activity Endpoint 37% Killing

Detail Source Activity Toxicity

Activity Measurement 128 µM

Toxicity Type Cytotoxic

Toxicity Raw

37% Killing | 128 | µM | target cell: Human umbilical vein cells EA.hy926

Target

Target Cell Human umbilical vein cells EA.hy926

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Characterization of the Bioactivity and Mechanism of Bactenecin Derivatives Against Food-Pathogens. | Front Microbiol | 2019

Evidence 19 Activity

Activity

Activity Endpoint 20% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

20% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Salt-resistant homodimeric bactenecin, a cathelicidin-derived antimicrobial peptide. | FEBS J | 2008

Evidence 20 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Salt-resistant homodimeric bactenecin, a cathelicidin-derived antimicrobial peptide. | FEBS J | 2008

Evidence 21 Hemolysis

Source & Reference

source APD_complete HemoPI PD_Hemolysis

Database Source APD_complete PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation.