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Peptide record

TPDB06816

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard

12 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB06816

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia dbACP Antifungipept CAFPdb AVPpred-BWR APD_complete PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 12-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

ILGTILGLLKSL

FASTA

>TPDB06816|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Hemolysis;Toxicity|length=12
ILGTILGLLKSL

Formula C59H109N13O15

Absent Amino Acids ARNDCEQHMFPWYV

Common Amino Acids L

Mass 1240.59

PI 10.10

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 7

Net Charge +1

Boman Index -2.14

Hydrophobicity 1.817

Aliphatic Index 227.50

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 5 K: 1 M: 0 F: 0 P: 0 S: 1 T: 1 W: 0 Y: 0 V: 0

Length

Formula

C59H109N13O15

Mass

1240.59

10.10

Net Charge

Boman Index

-2.14

Hydrophobicity

1.817

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 15 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against B. subtilis and S. aureus (MIC 15 ug/ml). Also, E. coli ML-35 (MIC 32-64 uM), S. aureus (MIC 4 uM), S. epidermidis (MIC 8 uM), and

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 32-64 µM

Target

Target Organism Escherichia coli ML-35

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against B. subtilis and S. aureus (MIC 15 ug/ml). Also, E. coli ML-35 (MIC 32-64 uM), S. aureus (MIC 4 uM), S. epidermidis (MIC 8 uM), and B. subtilis (MIC 4 uM).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ive against B. subtilis and S. aureus (MIC 15 ug/ml). Also, E. coli ML-35 (MIC 32-64 uM), S. aureus (MIC 4 uM), S. epidermidis (MIC 8 uM), and B. subtilis (MIC 4 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µM

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

s and S. aureus (MIC 15 ug/ml). Also, E. coli ML-35 (MIC 32-64 uM), S. aureus (MIC 4 uM), S. epidermidis (MIC 8 uM), and B. subtilis (MIC 4 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Also, E. coli ML-35 (MIC 32-64 uM), S. aureus (MIC 4 uM), S. epidermidis (MIC 8 uM), and B. subtilis (MIC 4 uM).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 15 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against B. subtilis and S. aureus (MIC 15 ug/ml). Also, E. coli ML-35 (MIC 32-64 uM), S. aureus (MIC 4 uM), S. epidermidis (MIC 8 uM), and

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 32-64 µM

Target

Target Organism Escherichia coli ML-35

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against B. subtilis and S. aureus (MIC 15 ug/ml). Also, E. coli ML-35 (MIC 32-64 uM), S. aureus (MIC 4 uM), S. epidermidis (MIC 8 uM), and B. subtilis (MIC 4 uM).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

ive against B. subtilis and S. aureus (MIC 15 ug/ml). Also, E. coli ML-35 (MIC 32-64 uM), S. aureus (MIC 4 uM), S. epidermidis (MIC 8 uM), and B. subtilis (MIC 4 uM).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8 µM

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

s and S. aureus (MIC 15 ug/ml). Also, E. coli ML-35 (MIC 32-64 uM), S. aureus (MIC 4 uM), S. epidermidis (MIC 8 uM), and B. subtilis (MIC 4 uM).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µM

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Also, E. coli ML-35 (MIC 32-64 uM), S. aureus (MIC 4 uM), S. epidermidis (MIC 8 uM), and B. subtilis (MIC 4 uM).

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 15 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against B. subtilis and S. aureus (MIC 15 ug/ml). Also, E. coli ML-35 (MIC 32-64 uM), S. aureus (MIC 4 uM), S. epidermidis (MIC 8 uM), and

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 32-64 µM

Target

Target Organism Escherichia coli ML-35

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against B. subtilis and S. aureus (MIC 15 ug/ml). Also, E. coli ML-35 (MIC 32-64 uM), S. aureus (MIC 4 uM), S. epidermidis (MIC 8 uM), and B. subtilis (MIC 4 uM).

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source DRAMP

Other

Evidence Text

ive against B. subtilis and S. aureus (MIC 15 ug/ml). Also, E. coli ML-35 (MIC 32-64 uM), S. aureus (MIC 4 uM), S. epidermidis (MIC 8 uM), and B. subtilis (MIC 4 uM).

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 8 µM

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source DRAMP

Other

Evidence Text

s and S. aureus (MIC 15 ug/ml). Also, E. coli ML-35 (MIC 32-64 uM), S. aureus (MIC 4 uM), S. epidermidis (MIC 8 uM), and B. subtilis (MIC 4 uM).

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4 µM

Target

Target Organism B. subtilis

Source & Reference

Database Source DRAMP

Other

Evidence Text

Also, E. coli ML-35 (MIC 32-64 uM), S. aureus (MIC 4 uM), S. epidermidis (MIC 8 uM), and B. subtilis (MIC 4 uM).

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 15 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets.

Evidence Text

Active against B. subtilis and S. aureus (MIC 15 ug/ml). Also, E. coli ML-35 (MIC 32-64 uM), S. aureus (MIC 4 uM), S. epidermidis (MIC 8 uM), and

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 32-64 µM

Target

Target Organism Escherichia coli ML-35

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against B. subtilis and S. aureus (MIC 15 ug/ml). Also, E. coli ML-35 (MIC 32-64 uM), S. aureus (MIC 4 uM), S. epidermidis (MIC 8 uM), and B. subtilis (MIC 4 uM).

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 4 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source DRAMP

Other

Evidence Text

ive against B. subtilis and S. aureus (MIC 15 ug/ml). Also, E. coli ML-35 (MIC 32-64 uM), S. aureus (MIC 4 uM), S. epidermidis (MIC 8 uM), and B. subtilis (MIC 4 uM).

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 8 µM

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source DRAMP

Other

Evidence Text

s and S. aureus (MIC 15 ug/ml). Also, E. coli ML-35 (MIC 32-64 uM), S. aureus (MIC 4 uM), S. epidermidis (MIC 8 uM), and B. subtilis (MIC 4 uM).

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 4 µM

Target

Target Organism B. subtilis

Source & Reference

Database Source DRAMP

Other

Evidence Text

Also, E. coli ML-35 (MIC 32-64 uM), S. aureus (MIC 4 uM), S. epidermidis (MIC 8 uM), and B. subtilis (MIC 4 uM).

Evidence 21 Activity

Activity

Activity Endpoint 52% degranulation

Detail Source Activity Toxicity

Activity Measurement 100 µM

Toxicity Type Cytotoxic

Toxicity Raw

52% degranulation | 100 | µM | target cell: Rat mast cells

Target

Target Cell Rat mast cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Structural and functional characterization of two novel peptide toxins isolated from the venom of the social wasp Polybia paulista | Peptides | 2005

Evidence 22 Activity

Activity

Activity Endpoint 78% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

78% Hemolysis | 100 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Structural and functional characterization of two novel peptide toxins isolated from the venom of the social wasp Polybia paulista | Peptides | 2005

Evidence 23 Activity

Activity

Activity Endpoint <20% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 30 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

<20% Hemolysis | 30 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antifungal effect and action mechanism of antimicrobial peptide polybia-CP. | J Pept Sci | 2016

Evidence 24 Activity

Activity

Activity Endpoint 62% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 60-130 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

62% Hemolysis | 60-130 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

D-amino acid substitution enhances the stability of antimicrobial peptide polybia-CP. | Acta Biochim Biophys Sin | 2017

Evidence 25 Hemolysis

Source & Reference

source APD_complete PD_Hemolysis

Database Source APD_complete PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation.