TPDB

3D PDB MODEL

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TPDB ID TPDB06814

Activity

Antibacterial Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 12-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and Antifungipept, with an available 3D structural model.

Sequence

HLGHHALDHLLK

FASTA

>TPDB06814|Antibacterial;Antifungal;Toxicity|length=12
HLGHHALDHLLK

Formula C63H99N21O15

Absent Amino Acids RNCEQIMFPSTWYV

Common Amino Acids HL

Mass 1390.61

PI 8.12

Basic Residues 5

Acidic Residues 1

Hydrophobic Residues 5

Net Charge +0

Boman Index 3.66

Hydrophobicity -0.300

Aliphatic Index 138.33

Half Life

Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

1

A

0

R

0

N

1

D

0

C

0

E

0

Q

1

G

4

H

0

I

4

L

1

K

0

M

0

F

0

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 4 I: 0 L: 4 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

12

Formula

C63H99N21O15

Mass

1390.61

PI

8.12

Net Charge

+0

Boman Index

3.66

Hydrophobicity

-0.300

Evidence 1 Activity

Activity

Activity Endpoint 1% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 1500-3200 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

1% Hemolysis | 1500-3200 | µg/mL | target cell: Rabbit erythrocytes

Target

Target Cell Rabbit erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Immune mediators of sea-cucumber Holothuria tubulosa (Echinodermata) as source of novel antimicrobial and anti-staphylococcal biofilm agents. | AMB Express | 2013

Evidence 2 Activity

Activity

Activity Endpoint 3% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 6200 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

3% Hemolysis | 6200 | µg/mL | target cell: Rabbit erythrocytes

Target

Target Cell Rabbit erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Immune mediators of sea-cucumber Holothuria tubulosa (Echinodermata) as source of novel antimicrobial and anti-staphylococcal biofilm agents. | AMB Express | 2013

Evidence 3 Activity

Activity

Activity Endpoint 12.5% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 50000 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

12.5% Hemolysis | 50000 | µg/mL | target cell: Rabbit erythrocytes

Target

Target Cell Rabbit erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Immune mediators of sea-cucumber Holothuria tubulosa (Echinodermata) as source of novel antimicrobial and anti-staphylococcal biofilm agents. | AMB Express | 2013