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Peptide record

TPDB06806

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard

12 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB06806

Activity

Antibacterial Anticancer Antifungal Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb PD_Hemolysis

Sequence_Type

standard

Has_Modification No

Description A 12-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

RRWRIVVIRVRR

FASTA

>TPDB06806|Antibacterial;Anticancer;Antifungal;Hemolysis;Toxicity|length=12
RRWRIVVIRVRR

Formula C74H133N31O13

Absent Amino Acids ANDCEQGHLKMFPSTY

Common Amino Acids R

Mass 1665.07

PI 13.10

Basic Residues 6

Acidic Residues 0

Hydrophobic Residues 6

Net Charge +6

Boman Index 2.60

Hydrophobicity -0.525

Aliphatic Index 137.50

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 5500

Absorbance 280nm 330.32

Polar Residues 0

number

Amino Acid Distribution

A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 3

Length

Formula

C74H133N31O13

Mass

1665.07

13.10

Net Charge

Boman Index

2.60

Hydrophobicity

-0.525

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µM

Target

Target Organism Pseudomonas aeruginosa H103

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

active against P. aeruginosa H103 (MIC 2 uM), E. coli (MIC 0.5 uM), S. enterica ssp. Typhimurium or S. Typhimurium (MIC 4 uM). S. aure

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.5 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against P. aeruginosa H103 (MIC 2 uM), E. coli (MIC 0.5 uM), S. enterica ssp. Typhimurium or S. Typhimurium (MIC 4 uM). S. aureus ATCC25923 (MIC 2 uM

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism S. Typhimurium

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

inst P. aeruginosa H103 (MIC 2 uM), E. coli (MIC 0.5 uM), S. enterica ssp. Typhimurium or S. Typhimurium (MIC 4 uM). S. aureus ATCC25923 (MIC 2 uM), S. epidermidis clinical strain (MIC 0.2 uM), E. faecalis

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µM

Target

Target Organism Staphylococcus aureus ATCC25923

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

C 2 uM), E. coli (MIC 0.5 uM), S. enterica ssp. Typhimurium or S. Typhimurium (MIC 4 uM). S. aureus ATCC25923 (MIC 2 uM), S. epidermidis clinical strain (MIC 0.2 uM), E. faecalis ATCC29212 (MIC 4 uM), and C. al

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.2 µM

Target

Target Organism Staphylococcus epidermidis clinical strain

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

. enterica ssp. Typhimurium or S. Typhimurium (MIC 4 uM). S. aureus ATCC25923 (MIC 2 uM), S. epidermidis clinical strain (MIC 0.2 uM), E. faecalis ATCC29212 (MIC 4 uM), and C. albicans (MIC 4 uM).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism Enterococcus faecalis ATCC29212

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

(MIC 4 uM). S. aureus ATCC25923 (MIC 2 uM), S. epidermidis clinical strain (MIC 0.2 uM), E. faecalis ATCC29212 (MIC 4 uM), and C. albicans (MIC 4 uM).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

2 uM), S. epidermidis clinical strain (MIC 0.2 uM), E. faecalis ATCC29212 (MIC 4 uM), and C. albicans (MIC 4 uM).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µM

Target

Target Organism Pseudomonas aeruginosa H103

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

active against P. aeruginosa H103 (MIC 2 uM), E. coli (MIC 0.5 uM), S. enterica ssp. Typhimurium or S. Typhimurium (MIC 4 uM). S. aure

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.5 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

active against P. aeruginosa H103 (MIC 2 uM), E. coli (MIC 0.5 uM), S. enterica ssp. Typhimurium or S. Typhimurium (MIC 4 uM). S. aureus ATCC25923 (MIC 2 uM

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µM

Target

Target Organism S. Typhimurium

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µM

Target

Target Organism Staphylococcus aureus ATCC25923

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.2 µM

Target

Target Organism Staphylococcus epidermidis clinical strain

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

. enterica ssp. Typhimurium or S. Typhimurium (MIC 4 uM). S. aureus ATCC25923 (MIC 2 uM), S. epidermidis clinical strain (MIC 0.2 uM), E. faecalis ATCC29212 (MIC 4 uM), and C. albicans (MIC 4 uM).

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µM

Target

Target Organism Enterococcus faecalis ATCC29212

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

(MIC 4 uM). S. aureus ATCC25923 (MIC 2 uM), S. epidermidis clinical strain (MIC 0.2 uM), E. faecalis ATCC29212 (MIC 4 uM), and C. albicans (MIC 4 uM).

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

2 uM), S. epidermidis clinical strain (MIC 0.2 uM), E. faecalis ATCC29212 (MIC 4 uM), and C. albicans (MIC 4 uM).

Evidence 15 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >50 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | >50 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

The antimicrobial activity of Sub3 is dependent on membrane binding and cell-penetrating ability. | Chembiochem | 2013

Evidence 16 Hemolysis

Source & Reference

source PD_Hemolysis

Database Source PD_Hemolysis