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Peptide record

TPDB06805

Antibacterial Anticancer Antifungal Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB06805
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RRWKIVVIRWRR
Physicochemical Analysis
C80H134N30O13
ANDCEQGHLMFPSTY
R
1724.14
13.00
6
0
6
+6
0.86
-0.900
113.33
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
638.00
0
Residue Composition
number
0
A
5
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 2
Chemical Descriptors
12
C80H134N30O13
1724.14
13.00
+6
0.86
-0.900
Evidence Records 16 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2 µM

Target

Pseudomonas aeruginosa H103

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against P. aeruginosa H103 (MIC 2 uM), E. coli (MIC 4 uM), S. enterica ssp. Typhimurium or S. Typhimurium (MIC 8 uM). S. aureus
Evidence 2 Activity

Activity

MIC
Antibacterial
4 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

active against P. aeruginosa H103 (MIC 2 uM), E. coli (MIC 4 uM), S. enterica ssp. Typhimurium or S. Typhimurium (MIC 8 uM). S. aureus ATCC25923 (MIC 2 uM
Evidence 3 Activity

Activity

MIC
Antibacterial
8 µM

Target

S. Typhimurium

Source & Reference

dbAMP DRAMP

Other

gainst P. aeruginosa H103 (MIC 2 uM), E. coli (MIC 4 uM), S. enterica ssp. Typhimurium or S. Typhimurium (MIC 8 uM). S. aureus ATCC25923 (MIC 2 uM), S. epidermidis clinical strain (MIC 0.5 uM), E. faecalis
Evidence 4 Activity

Activity

MIC
Antibacterial
2 µM

Target

Staphylococcus aureus ATCC25923

Source & Reference

dbAMP DRAMP

Other

MIC 2 uM), E. coli (MIC 4 uM), S. enterica ssp. Typhimurium or S. Typhimurium (MIC 8 uM). S. aureus ATCC25923 (MIC 2 uM), S. epidermidis clinical strain (MIC 0.5 uM), E. faecalis ATCC29212 (MIC 2 uM), and C. al
Evidence 5 Activity

Activity

MIC
Antibacterial
0.5 µM

Target

Staphylococcus epidermidis clinical strain

Source & Reference

dbAMP DRAMP

Other

. enterica ssp. Typhimurium or S. Typhimurium (MIC 8 uM). S. aureus ATCC25923 (MIC 2 uM), S. epidermidis clinical strain (MIC 0.5 uM), E. faecalis ATCC29212 (MIC 2 uM), and C. albicans (MIC 4 uM).
Evidence 6 Activity

Activity

MIC
Antibacterial
2 µM

Target

Enterococcus faecalis ATCC29212

Source & Reference

dbAMP DRAMP

Other

(MIC 8 uM). S. aureus ATCC25923 (MIC 2 uM), S. epidermidis clinical strain (MIC 0.5 uM), E. faecalis ATCC29212 (MIC 2 uM), and C. albicans (MIC 4 uM).
Evidence 7 Activity

Activity

MIC
Antibacterial
4 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

2 uM), S. epidermidis clinical strain (MIC 0.5 uM), E. faecalis ATCC29212 (MIC 2 uM), and C. albicans (MIC 4 uM).
Evidence 8 Activity

Activity

MIC
Antifungal
2 µM

Target

Pseudomonas aeruginosa H103

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
active against P. aeruginosa H103 (MIC 2 uM), E. coli (MIC 4 uM), S. enterica ssp. Typhimurium or S. Typhimurium (MIC 8 uM). S. aureus
Evidence 9 Activity

Activity

MIC
Antifungal
4 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

active against P. aeruginosa H103 (MIC 2 uM), E. coli (MIC 4 uM), S. enterica ssp. Typhimurium or S. Typhimurium (MIC 8 uM). S. aureus ATCC25923 (MIC 2 uM
Evidence 10 Activity

Activity

MIC
Antifungal
8 µM

Target

S. Typhimurium

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

gainst P. aeruginosa H103 (MIC 2 uM), E. coli (MIC 4 uM), S. enterica ssp. Typhimurium or S. Typhimurium (MIC 8 uM). S. aureus ATCC25923 (MIC 2 uM), S. epidermidis clinical strain (MIC 0.5 uM), E. faecalis
Evidence 11 Activity

Activity

MIC
Antifungal
2 µM

Target

Staphylococcus aureus ATCC25923

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

MIC 2 uM), E. coli (MIC 4 uM), S. enterica ssp. Typhimurium or S. Typhimurium (MIC 8 uM). S. aureus ATCC25923 (MIC 2 uM), S. epidermidis clinical strain (MIC 0.5 uM), E. faecalis ATCC29212 (MIC 2 uM), and C. al
Evidence 12 Activity

Activity

MIC
Antifungal
0.5 µM

Target

Staphylococcus epidermidis clinical strain

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

. enterica ssp. Typhimurium or S. Typhimurium (MIC 8 uM). S. aureus ATCC25923 (MIC 2 uM), S. epidermidis clinical strain (MIC 0.5 uM), E. faecalis ATCC29212 (MIC 2 uM), and C. albicans (MIC 4 uM).
Evidence 13 Activity

Activity

MIC
Antifungal
2 µM

Target

Enterococcus faecalis ATCC29212

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

(MIC 8 uM). S. aureus ATCC25923 (MIC 2 uM), S. epidermidis clinical strain (MIC 0.5 uM), E. faecalis ATCC29212 (MIC 2 uM), and C. albicans (MIC 4 uM).
Evidence 14 Activity

Activity

MIC
Antifungal
4 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

2 uM), S. epidermidis clinical strain (MIC 0.5 uM), E. faecalis ATCC29212 (MIC 2 uM), and C. albicans (MIC 4 uM).
Evidence 15 Activity

Activity

0% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 256 | µg/mL | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Comparative Evaluation of the Antimicrobial Activity of Different Antimicrobial Peptides against a Range of Pathogenic Bacteria. | PLoS One | 2015
Evidence 16 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human dermal fibroblasts

Target

Human dermal fibroblasts

Source & Reference

NA
DBAASP
Cu-ATCUN Derivatives of Sub5 Exhibit Enhanced Antimicrobial Activity via Multiple Modes of Action. | ACS Chem Biol | 2019