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Peptide record

TPDB06802

Antibacterial Anticancer Antifungal Toxicity standard

12 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB06802

Activity

Antibacterial Anticancer Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia SATPdb dbACP AFP-GFuse Antifungipept CAFPdb dbAMP ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 12-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, SATPdb, and other sources, with an available 3D structural model.

Sequence

ILPIRSLIKKLL

FASTA

>TPDB06802|Antibacterial;Anticancer;Antifungal;Toxicity|length=12
ILPIRSLIKKLL

Formula C68H127N17O14

Absent Amino Acids ANDCEQGHMFTWYV

Common Amino Acids L

Mass 1406.86

PI 11.64

Basic Residues 3

Acidic Residues 0

Hydrophobic Residues 7

Net Charge +3

Boman Index 0.20

Hydrophobicity 1.167

Aliphatic Index 227.50

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 3 L: 4 K: 2 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 0

Length

Formula

C68H127N17O14

Mass

1406.86

11.64

Net Charge

Boman Index

0.20

Hydrophobicity

1.167

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

Active against E. coli, P. aeruginosa (MIC 25 uM), S. aureus (MIC 12.5 uM), B. cereus, S. lactis (MIC 6.25 uM), C. albicans (MIC 12.5 uM),

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 12.5 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP

Other

Evidence Text

Active against E. coli, P. aeruginosa (MIC 25 uM), S. aureus (MIC 12.5 uM), B. cereus, S. lactis (MIC 6.25 uM), C. albicans (MIC 12.5 uM), and cancer cells MCF 7 ce

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.25 µM

Target

Target Organism S. lactis

Source & Reference

Database Source dbAMP

Other

Evidence Text

Active against E. coli, P. aeruginosa (MIC 25 uM), S. aureus (MIC 12.5 uM), B. cereus, S. lactis (MIC 6.25 uM), C. albicans (MIC 12.5 uM), and cancer cells MCF 7 cells and Hela cells (IC50 ~25 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 12.5 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP

Other

Evidence Text

, P. aeruginosa (MIC 25 uM), S. aureus (MIC 12.5 uM), B. cereus, S. lactis (MIC 6.25 uM), C. albicans (MIC 12.5 uM), and cancer cells MCF 7 cells and Hela cells (IC50 ~25 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

Active against E. coli, P. aeruginosa (MIC 25 uM), S. aureus (MIC 12.5 uM), B. cereus, S. lactis (MIC 6.25 uM), C. albicans (MIC 12.5 uM),

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 12.5 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli, P. aeruginosa (MIC 25 uM), S. aureus (MIC 12.5 uM), B. cereus, S. lactis (MIC 6.25 uM), C. albicans (MIC 12.5 uM), and cancer cells MCF 7 ce

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.25 µM

Target

Target Organism S. lactis

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli, P. aeruginosa (MIC 25 uM), S. aureus (MIC 12.5 uM), B. cereus, S. lactis (MIC 6.25 uM), C. albicans (MIC 12.5 uM), and cancer cells MCF 7 cells and Hela cells (IC50 ~25 uM).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 12.5 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

, P. aeruginosa (MIC 25 uM), S. aureus (MIC 12.5 uM), B. cereus, S. lactis (MIC 6.25 uM), C. albicans (MIC 12.5 uM), and cancer cells MCF 7 cells and Hela cells (IC50 ~25 uM).

Evidence 9 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 105.2±10.2 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 105.2±10.2 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Purification, molecular cloning, and antimicrobial activity of peptides from the skin secretion of the black-spotted frog, Rana nigromaculata. | World J Microbiol Biotechnol | 2013

Evidence 10 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

World J Microbiol Biotechnol. 2013 Oct 29(10):1941-9.