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Peptide record

TPDB06795

Antibacterial Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB06795
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 12-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
VQLRIRVAVIRA
Physicochemical Analysis
C62H116N22O14
NDCEGHKMFPSTWY
RV
1393.74
12.70
3
0
8
+3
1.70
1.000
186.67
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
2
A
3
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
2
I
1
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 2 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 2 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 3
Chemical Descriptors
12
C62H116N22O14
1393.74
12.70
+3
1.70
1.000
Evidence Records 8 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6 µg/mL

Target

Escherichia coli

Source & Reference

NA

Other

active against P-aeruginosa PAO1 (MIC >50 ug/ml), E. coli (MIC 6 ug/ml), S. typhimurium (MIC 12 ug/ml), S. aureus (MIC 50 ug/ml), S. epidermidis (MIC 12 ug/ml),
Evidence 2 Activity

Activity

MIC
Antibacterial
12 µg/mL

Target

S. typhimurium

Source & Reference

NA

Other

active against P-aeruginosa PAO1 (MIC >50 ug/ml), E. coli (MIC 6 ug/ml), S. typhimurium (MIC 12 ug/ml), S. aureus (MIC 50 ug/ml), S. epidermidis (MIC 12 ug/ml), E. faecalis ATCC29212 (MIC 50 u
Evidence 3 Activity

Activity

MIC
Antibacterial
50 µg/mL

Target

Staphylococcus aureus

Source & Reference

NA

Other

P-aeruginosa PAO1 (MIC >50 ug/ml), E. coli (MIC 6 ug/ml), S. typhimurium (MIC 12 ug/ml), S. aureus (MIC 50 ug/ml), S. epidermidis (MIC 12 ug/ml), E. faecalis ATCC29212 (MIC 50 ug/ml), and C. albicans (MI
Evidence 4 Activity

Activity

MIC
Antibacterial
12 µg/mL

Target

Staphylococcus epidermidis

Source & Reference

NA

Other

0 ug/ml), E. coli (MIC 6 ug/ml), S. typhimurium (MIC 12 ug/ml), S. aureus (MIC 50 ug/ml), S. epidermidis (MIC 12 ug/ml), E. faecalis ATCC29212 (MIC 50 ug/ml), and C. albicans (MIC 25 ug/ml).
Evidence 5 Activity

Activity

MIC
Antibacterial
50 µg/mL

Target

Enterococcus faecalis ATCC29212

Source & Reference

NA

Other

, S. typhimurium (MIC 12 ug/ml), S. aureus (MIC 50 ug/ml), S. epidermidis (MIC 12 ug/ml), E. faecalis ATCC29212 (MIC 50 ug/ml), and C. albicans (MIC 25 ug/ml).
Evidence 6 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

Candida albicans

Source & Reference

NA

Other

(MIC 50 ug/ml), S. epidermidis (MIC 12 ug/ml), E. faecalis ATCC29212 (MIC 50 ug/ml), and C. albicans (MIC 25 ug/ml).
Evidence 7 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human monocytes

Target

Human monocytes

Source & Reference

NA
DBAASP
Ability of innate defence regulator peptides IDR-1002, IDR-HH2 and IDR-1018 to protect against Mycobacterium tuberculosis infections in animal models. | PLoS One | 2013
Evidence 8 Activity

Activity

50% Hemolysis
Toxicity
415 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 415 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
In vitro and in vivo activities of antimicrobial peptides developed using an amino acid-based activity prediction method. | Antimicrob Agents Chemother | 2014