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Peptide record

TPDB06794

Antibacterial Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB06794
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 12-aa standard-residue multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
LCAAHCLAIRRR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C57H103N23O13S2
NDEQGKMFPSTWYV
AR
1382.71
10.82
4
0
6
+3
2.22
0.483
122.50
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
125
0.09
2
Residue Composition
number
3
A
3
R
0
N
0
D
2
C
0
E
0
Q
0
G
1
H
1
I
2
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 3 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 1 I: 1 L: 2 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
12 reviewed residue count
C57H103N23O13S2 sequence-only estimate (linear, free termini)
1382.71 sequence-only estimate (linear, free termini)
10.82 sequence-only estimate (linear, free termini)
+3 sequence-only estimate (linear, free termini)
2.22 sequence-only estimate (linear, free termini)
0.483 sequence-only estimate (linear, free termini)
Evidence Records 1 records
Evidence 1 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Synthesis and characterization of bactericidal oligopeptides designed on the basis of an insect anti-bacterial peptide. | Biochem J | 1999