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Peptide record

TPDB06788

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB06788
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab Antifungipept CAFPdb dbAMP
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, ACP740 _ACP240, and other sources, with an available 3D structural model.
Sequence
ILRWPWWPWRRK
Physicochemical Analysis
C90H126N26O13
ANDCEQGHMFSTYV
W
1780.16
12.71
4
0
6
+4
-3.95
-1.325
65.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
22000
1235.85
0
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
1
L
1
K
0
M
0
F
2
P
0
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 1 M: 0 F: 0 P: 2 S: 0 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
12
C90H126N26O13
1780.16
12.71
+4
-3.95
-1.325
Evidence Records 32 records
Evidence 1 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

Enterococcus faecalis PCM 2673

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against Gram+ E. faecalis PCM 2673 (MIC 16 ug/ml), S. aureus ATCC 25923 or 9144 (MIC 16 ug/ml), S. pneumoniae ATCC 49619 (MIC 8 ug/ml), Gra
Evidence 2 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

Staphylococcus aureus ATCC 25923 or 9144

Source & Reference

dbAMP

Other

active against Gram+ E. faecalis PCM 2673 (MIC 16 ug/ml), S. aureus ATCC 25923 or 9144 (MIC 16 ug/ml), S. pneumoniae ATCC 49619 (MIC 8 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 16-32 ug/
Evidence 3 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

S. pneumoniae ATCC 49619

Source & Reference

dbAMP

Other

t Gram+ E. faecalis PCM 2673 (MIC 16 ug/ml), S. aureus ATCC 25923 or 9144 (MIC 16 ug/ml), S. pneumoniae ATCC 49619 (MIC 8 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 16-32 ug/ml), K. pneumoniae ATCC 700603 (MIC 8 ug
Evidence 4 Activity

Activity

MIC
Antibacterial
16-32 µg/mL

Target

Escherichia coli ATCC 25922 or 23506

Source & Reference

dbAMP

Other

. aureus ATCC 25923 or 9144 (MIC 16 ug/ml), S. pneumoniae ATCC 49619 (MIC 8 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 16-32 ug/ml), K. pneumoniae ATCC 700603 (MIC 8 ug/ml), P. aeruginosa ATCC 9027 (MIC 16 ug/ml), fungi A
Evidence 5 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

Klebsiella pneumoniae ATCC 700603

Source & Reference

dbAMP

Other

pneumoniae ATCC 49619 (MIC 8 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 16-32 ug/ml), K. pneumoniae ATCC 700603 (MIC 8 ug/ml), P. aeruginosa ATCC 9027 (MIC 16 ug/ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albi
Evidence 6 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

Pseudomonas aeruginosa ATCC 9027

Source & Reference

dbAMP

Other

- E. coli ATCC 25922 or 23506 (MIC 16-32 ug/ml), K. pneumoniae ATCC 700603 (MIC 8 ug/ml), P. aeruginosa ATCC 9027 (MIC 16 ug/ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albicans ATCC 10231 (MIC 128 ug/ml), and C.g
Evidence 7 Activity

Activity

MIC
Antibacterial
64 µg/mL

Target

A. niger ATCC 16404

Source & Reference

dbAMP

Other

), K. pneumoniae ATCC 700603 (MIC 8 ug/ml), P. aeruginosa ATCC 9027 (MIC 16 ug/ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albicans ATCC 10231 (MIC 128 ug/ml), and C.glabrata ATCC 15126 (MIC 128 ug/ml).
Evidence 8 Activity

Activity

MIC
Antibacterial
128 µg/mL

Target

C.albicans ATCC 10231

Source & Reference

dbAMP

Other

ug/ml), P. aeruginosa ATCC 9027 (MIC 16 ug/ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albicans ATCC 10231 (MIC 128 ug/ml), and C.glabrata ATCC 15126 (MIC 128 ug/ml).
Evidence 9 Activity

Activity

MIC
Antibacterial
128 µg/mL

Target

C.glabrata ATCC 15126

Source & Reference

dbAMP

Other

ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albicans ATCC 10231 (MIC 128 ug/ml), and C.glabrata ATCC 15126 (MIC 128 ug/ml).
Evidence 10 Activity

Activity

MIC
Antifungal
16 µg/mL

Target

Enterococcus faecalis PCM 2673

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
active against Gram+ E. faecalis PCM 2673 (MIC 16 ug/ml), S. aureus ATCC 25923 or 9144 (MIC 16 ug/ml), S. pneumoniae ATCC 49619 (MIC 8 ug/ml), Gra
Evidence 11 Activity

Activity

MIC
Antifungal
16 µg/mL

Target

Staphylococcus aureus ATCC 25923 or 9144

Source & Reference

dbAMP CAFPdb Antifungipept

Other

active against Gram+ E. faecalis PCM 2673 (MIC 16 ug/ml), S. aureus ATCC 25923 or 9144 (MIC 16 ug/ml), S. pneumoniae ATCC 49619 (MIC 8 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 16-32 ug/
Evidence 12 Activity

Activity

MIC
Antifungal
8 µg/mL

Target

S. pneumoniae ATCC 49619

Source & Reference

dbAMP CAFPdb Antifungipept

Other

t Gram+ E. faecalis PCM 2673 (MIC 16 ug/ml), S. aureus ATCC 25923 or 9144 (MIC 16 ug/ml), S. pneumoniae ATCC 49619 (MIC 8 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 16-32 ug/ml), K. pneumoniae ATCC 700603 (MIC 8 ug
Evidence 13 Activity

Activity

MIC
Antifungal
16-32 µg/mL

Target

Escherichia coli ATCC 25922 or 23506

Source & Reference

dbAMP CAFPdb Antifungipept

Other

. aureus ATCC 25923 or 9144 (MIC 16 ug/ml), S. pneumoniae ATCC 49619 (MIC 8 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 16-32 ug/ml), K. pneumoniae ATCC 700603 (MIC 8 ug/ml), P. aeruginosa ATCC 9027 (MIC 16 ug/ml), fungi A
Evidence 14 Activity

Activity

MIC
Antifungal
8 µg/mL

Target

Klebsiella pneumoniae ATCC 700603

Source & Reference

dbAMP CAFPdb Antifungipept

Other

pneumoniae ATCC 49619 (MIC 8 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 16-32 ug/ml), K. pneumoniae ATCC 700603 (MIC 8 ug/ml), P. aeruginosa ATCC 9027 (MIC 16 ug/ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albi
Evidence 15 Activity

Activity

MIC
Antifungal
16 µg/mL

Target

Pseudomonas aeruginosa ATCC 9027

Source & Reference

dbAMP CAFPdb Antifungipept

Other

- E. coli ATCC 25922 or 23506 (MIC 16-32 ug/ml), K. pneumoniae ATCC 700603 (MIC 8 ug/ml), P. aeruginosa ATCC 9027 (MIC 16 ug/ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albicans ATCC 10231 (MIC 128 ug/ml), and C.g
Evidence 16 Activity

Activity

MIC
Antifungal
64 µg/mL

Target

A. niger ATCC 16404

Source & Reference

dbAMP CAFPdb Antifungipept

Other

), K. pneumoniae ATCC 700603 (MIC 8 ug/ml), P. aeruginosa ATCC 9027 (MIC 16 ug/ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albicans ATCC 10231 (MIC 128 ug/ml), and C.glabrata ATCC 15126 (MIC 128 ug/ml).
Evidence 17 Activity

Activity

MIC
Antifungal
128 µg/mL

Target

C.albicans ATCC 10231

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ug/ml), P. aeruginosa ATCC 9027 (MIC 16 ug/ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albicans ATCC 10231 (MIC 128 ug/ml), and C.glabrata ATCC 15126 (MIC 128 ug/ml).
Evidence 18 Activity

Activity

MIC
Antifungal
128 µg/mL

Target

C.glabrata ATCC 15126

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albicans ATCC 10231 (MIC 128 ug/ml), and C.glabrata ATCC 15126 (MIC 128 ug/ml).
Evidence 19 Activity

Activity

MIC
Antiparasitic
16 µg/mL

Target

Enterococcus faecalis PCM 2673

Source & Reference

NA

Other

active against Gram+ E. faecalis PCM 2673 (MIC 16 ug/ml), S. aureus ATCC 25923 or 9144 (MIC 16 ug/ml), S. pneumoniae ATCC 49619 (MIC 8 ug/ml), Gra
Evidence 20 Activity

Activity

MIC
Antiparasitic
16 µg/mL

Target

Staphylococcus aureus ATCC 25923 or 9144

Source & Reference

NA

Other

active against Gram+ E. faecalis PCM 2673 (MIC 16 ug/ml), S. aureus ATCC 25923 or 9144 (MIC 16 ug/ml), S. pneumoniae ATCC 49619 (MIC 8 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 16-32 ug/
Evidence 21 Activity

Activity

MIC
Antiparasitic
8 µg/mL

Target

S. pneumoniae ATCC 49619

Source & Reference

NA

Other

t Gram+ E. faecalis PCM 2673 (MIC 16 ug/ml), S. aureus ATCC 25923 or 9144 (MIC 16 ug/ml), S. pneumoniae ATCC 49619 (MIC 8 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 16-32 ug/ml), K. pneumoniae ATCC 700603 (MIC 8 ug
Evidence 22 Activity

Activity

MIC
Antiparasitic
16-32 µg/mL

Target

Escherichia coli ATCC 25922 or 23506

Source & Reference

NA

Other

. aureus ATCC 25923 or 9144 (MIC 16 ug/ml), S. pneumoniae ATCC 49619 (MIC 8 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 16-32 ug/ml), K. pneumoniae ATCC 700603 (MIC 8 ug/ml), P. aeruginosa ATCC 9027 (MIC 16 ug/ml), fungi A
Evidence 23 Activity

Activity

MIC
Antiparasitic
8 µg/mL

Target

Klebsiella pneumoniae ATCC 700603

Source & Reference

NA

Other

pneumoniae ATCC 49619 (MIC 8 ug/ml), Gram- E. coli ATCC 25922 or 23506 (MIC 16-32 ug/ml), K. pneumoniae ATCC 700603 (MIC 8 ug/ml), P. aeruginosa ATCC 9027 (MIC 16 ug/ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albi
Evidence 24 Activity

Activity

MIC
Antiparasitic
16 µg/mL

Target

Pseudomonas aeruginosa ATCC 9027

Source & Reference

NA

Other

- E. coli ATCC 25922 or 23506 (MIC 16-32 ug/ml), K. pneumoniae ATCC 700603 (MIC 8 ug/ml), P. aeruginosa ATCC 9027 (MIC 16 ug/ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albicans ATCC 10231 (MIC 128 ug/ml), and C.g
Evidence 25 Activity

Activity

MIC
Antiparasitic
64 µg/mL

Target

A. niger ATCC 16404

Source & Reference

NA

Other

), K. pneumoniae ATCC 700603 (MIC 8 ug/ml), P. aeruginosa ATCC 9027 (MIC 16 ug/ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albicans ATCC 10231 (MIC 128 ug/ml), and C.glabrata ATCC 15126 (MIC 128 ug/ml).
Evidence 26 Activity

Activity

MIC
Antiparasitic
128 µg/mL

Target

C.albicans ATCC 10231

Source & Reference

NA

Other

ug/ml), P. aeruginosa ATCC 9027 (MIC 16 ug/ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albicans ATCC 10231 (MIC 128 ug/ml), and C.glabrata ATCC 15126 (MIC 128 ug/ml).
Evidence 27 Activity

Activity

MIC
Antiparasitic
128 µg/mL

Target

C.glabrata ATCC 15126

Source & Reference

NA

Other

ml), fungi A. niger ATCC 16404 (MIC 64 ug/ml), C.albicans ATCC 10231 (MIC 128 ug/ml), and C.glabrata ATCC 15126 (MIC 128 ug/ml).
Evidence 28 Activity

Activity

5% Hemolysis
Toxicity
160 µg/mL
Hemolytic Cytotoxic
5% Hemolysis | 160 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
De novo generation of short antimicrobial peptides with simple amino acid composition | Regul Pept | 2011
Evidence 29 Activity

Activity

23% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
23% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Discovery of an ultra-short linear antibacterial tetrapeptide with anti-MRSA activity from a structure-activity relationship study. | Eur J Med Chem | 2015
Evidence 30 Activity

Activity

IC50
Toxicity
79.39 µg/mL
Cytotoxic
IC50 | 79.39 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Antimicrobial Activity of Selected Antimicrobial Peptides Against Planktonic Culture and Biofilm of Acinetobacter baumannii. | Probiotics Antimicrob Proteins | 2018
Evidence 31 Activity

Activity

50% Hemolysis
Toxicity
>512 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >512 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Discovering highly potent antimicrobial peptides with deep generative model HydrAMP. | Nat Commun | 2023
Evidence 32 Activity

Activity

11% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
11% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Potent antimicrobial peptides with selectivity for Bacillus anthracis over human erythrocytes. | Int J Antimicrob Agents | 2011