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Peptide record

TPDB06787

Antibacterial Antifungal Toxicity standard

12 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB06787

Activity

Antibacterial Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia Antifungipept ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 12-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

YSKSLPLSVLNP

FASTA

>TPDB06787|Antibacterial;Antifungal;Toxicity|length=12
YSKSLPLSVLNP

Formula C61H100N14O18

Absent Amino Acids ARDCEQGHIMFTW

Common Amino Acids LS

Mass 1317.55

PI 9.74

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 5

Net Charge +1

Boman Index 0.15

Hydrophobicity 0.108

Aliphatic Index 121.67

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 113.09

Polar Residues 5

number

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 3 K: 1 M: 0 F: 0 P: 2 S: 3 T: 0 W: 0 Y: 1 V: 1

Length

Formula

C61H100N14O18

Mass

1317.55

9.74

Net Charge

Boman Index

0.15

Hydrophobicity

0.108

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4-8 µg/mL

Target

Target Organism S. enteritidis ATCC 13076

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

active against S. enteritidis ATCC 13076 (MIC 4-8 ug/ml), E. coli (MIC 4-8 ug/ml) Enterobacter spp. (MIC 16-32 ug/ml), S. marcescens (MIC 16-32 u

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4-8 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against S. enteritidis ATCC 13076 (MIC 4-8 ug/ml), E. coli (MIC 4-8 ug/ml) Enterobacter spp. (MIC 16-32 ug/ml), S. marcescens (MIC 16-32 ug/ml), L. plantarum ATCC

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16-32 µg/mL

Target

Target Organism S. marcescens

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ATCC 13076 (MIC 4-8 ug/ml), E. coli (MIC 4-8 ug/ml) Enterobacter spp. (MIC 16-32 ug/ml), S. marcescens (MIC 16-32 ug/ml), L. plantarum ATCC 8014 (MIC 16-32 ug/ml), B. subtilis (MIC 16-32 ug/ml) B. cereus ATCC

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16-32 µg/mL

Target

Target Organism L. plantarum ATCC 8014

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

li (MIC 4-8 ug/ml) Enterobacter spp. (MIC 16-32 ug/ml), S. marcescens (MIC 16-32 ug/ml), L. plantarum ATCC 8014 (MIC 16-32 ug/ml), B. subtilis (MIC 16-32 ug/ml) B. cereus ATCC 14579 (MIC 64 ug/ml), S. aureus (MIC 64 ug

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16-32 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

16-32 ug/ml), S. marcescens (MIC 16-32 ug/ml), L. plantarum ATCC 8014 (MIC 16-32 ug/ml), B. subtilis (MIC 16-32 ug/ml) B. cereus ATCC 14579 (MIC 64 ug/ml), S. aureus (MIC 64 ug/ml) and B.anthracis (MIC 128

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 64 µg/mL

Target

Target Organism B. cereus ATCC 14579

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

IC 16-32 ug/ml), L. plantarum ATCC 8014 (MIC 16-32 ug/ml), B. subtilis (MIC 16-32 ug/ml) B. cereus ATCC 14579 (MIC 64 ug/ml), S. aureus (MIC 64 ug/ml) and B.anthracis (MIC 128 ug/ml).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 64 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

14 (MIC 16-32 ug/ml), B. subtilis (MIC 16-32 ug/ml) B. cereus ATCC 14579 (MIC 64 ug/ml), S. aureus (MIC 64 ug/ml) and B.anthracis (MIC 128 ug/ml).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 128 µg/mL

Target

Target Organism B.anthracis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

lis (MIC 16-32 ug/ml) B. cereus ATCC 14579 (MIC 64 ug/ml), S. aureus (MIC 64 ug/ml) and B.anthracis (MIC 128 ug/ml).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4-8 µg/mL

Target

Target Organism S. enteritidis ATCC 13076

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

active against S. enteritidis ATCC 13076 (MIC 4-8 ug/ml), E. coli (MIC 4-8 ug/ml) Enterobacter spp. (MIC 16-32 ug/ml), S. marcescens (MIC 16-32 u

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4-8 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

active against S. enteritidis ATCC 13076 (MIC 4-8 ug/ml), E. coli (MIC 4-8 ug/ml) Enterobacter spp. (MIC 16-32 ug/ml), S. marcescens (MIC 16-32 ug/ml), L. plantarum ATCC

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 16-32 µg/mL

Target

Target Organism S. marcescens

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 16-32 µg/mL

Target

Target Organism L. plantarum ATCC 8014

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 16-32 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 64 µg/mL

Target

Target Organism B. cereus ATCC 14579

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

IC 16-32 ug/ml), L. plantarum ATCC 8014 (MIC 16-32 ug/ml), B. subtilis (MIC 16-32 ug/ml) B. cereus ATCC 14579 (MIC 64 ug/ml), S. aureus (MIC 64 ug/ml) and B.anthracis (MIC 128 ug/ml).

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 64 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

14 (MIC 16-32 ug/ml), B. subtilis (MIC 16-32 ug/ml) B. cereus ATCC 14579 (MIC 64 ug/ml), S. aureus (MIC 64 ug/ml) and B.anthracis (MIC 128 ug/ml).

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 128 µg/mL

Target

Target Organism B.anthracis

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

lis (MIC 16-32 ug/ml) B. cereus ATCC 14579 (MIC 64 ug/ml), S. aureus (MIC 64 ug/ml) and B.anthracis (MIC 128 ug/ml).

Evidence 17 Activity

Activity

Activity Endpoint 5% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 256 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

5% Hemolysis | 256 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Production of an Antimicrobial Peptide AN5-1 in Escherichia coli and its Dual Mechanisms Against Bacteria. | Chem Biol Drug Des | 2015