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Peptide record

TPDB06783

Halictine 1 Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB06783
Halictine 1
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF AFP-GFuse Antifungipept CAFPdb APD_complete APD_hemolytic Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GMWSKILGHLIR
Physicochemical Analysis
C65H107N19O14S1
ANDCEQFPTYV
GIL
1410.74
11.49
3
0
6
+2
-0.91
0.367
130.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
389.87
1
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
2
G
1
H
2
I
2
L
1
K
1
M
0
F
0
P
1
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 1 I: 2 L: 2 K: 1 M: 1 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
12
C65H107N19O14S1
1410.74
11.49
+2
-0.91
0.367
Free
L
Not Available
Free
Anticancer
venom, the eusocial bee, Halictus sexcinctus
Evidence Records 7 records
Evidence 1 Activity

Activity

Not Available
Anticancer

Target

Not Available
Not Available
Not Available

Assay & Model

Not Available
Not Available

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2010

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

LC50
Hemolysis
82 µM
[Ref.20198492] LC50=82µM against rat red blood cells

Target

rat red blood cells

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Amino Acids. 2010 Aug 39(3):763-75.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
82 µM
Hemolytic Cytotoxic
50% Hemolysis | 82 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Evidence 4 Activity

Activity

IC50
Toxicity
48±19 µM
Cytotoxic
IC50 | 48±19 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells. | Peptides | 2012
Evidence 5 Activity

Activity

IC50
Toxicity
38±2 µM
Cytotoxic
IC50 | 38±2 | µM | target cell: Rat epithelial cells IEC-6, CRL-1592

Target

Rat epithelial cells IEC-6, CRL-1592

Source & Reference

NA
DBAASP
Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells. | Peptides | 2012
Evidence 6 Activity

Activity

LC50
Toxicity
82 µM
Hemolytic
Hemolytic_activity: [Ref.20198492] LC50=82µM against rat red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Amino Acids. 2010 Aug 39(3):763-75.
Evidence 7 Hemolysis

Activity

82 µM
LC50
[Ref.20198492] LC50=82µM against rat red blood cells
Hemolysis

Target

rat red blood cells

Source & Reference

APD_complete APD_hemolytic PD_Hemolysis
Amino Acids. 2010 Aug 39(3):763-75.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.