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Peptide record

TPDB06777

Antibacterial Antifungal Antiparasitic Hemolysis Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB06777
Antibacterial Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP dbAMP 3.0 HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
TLLKKVLKAAAK
Physicochemical Analysis
C60H114N16O14
RNDCEQGHIMFPSWY
K
1283.66
11.00
4
0
7
+4
1.98
0.392
146.67
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
3
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
3
L
4
K
0
M
0
F
0
P
0
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 3 K: 4 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
12
C60H114N16O14
1283.66
11.00
+4
1.98
0.392
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>80 µM
Hemolytic Cytotoxic
50% Hemolysis | >80 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationship study of antimicrobial dermaseptin S4 showing the consequences of peptide oligomerization on selective cytotoxicity | J Biol Chem | 2000
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
>50 µM
Hemolytic Cytotoxic
50% Hemolysis | >50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structural requirements for potent versus selective cytotoxicity for antimicrobial dermaseptin S4 derivatives. | J Biol Chem | 2002
Evidence 3 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis