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Peptide record

TPDB06774

Antibacterial Antifungal Hemolysis Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB06774
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
RRGWALRLVLAY
Physicochemical Analysis
C69H112N22O14
NDCEQHIKMFPST
RL
1473.79
12.11
3
0
8
+3
-2.30
0.258
138.33
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
6990
474.29
1
Residue Composition
number
2
A
3
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
3
L
0
K
0
M
0
F
0
P
0
S
0
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 2 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 3 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 1 V: 1
Chemical Descriptors
12
C69H112N22O14
1473.79
12.11
+3
-2.30
0.258
Evidence Records 5 records
Evidence 1 Activity

Activity

19% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
19% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Synthetic molecular evolution of host cell-compatible, antimicrobial peptides effective against drug-resistant, biofilm-forming bacteria. | Proc Natl Acad Sci U S A | 2020
Evidence 2 Activity

Activity

50% Cell death
Toxicity
>200 µM
Cytotoxic
50% Cell death | >200 | µM | target cell: Human fibroblasts WI-38

Target

Human fibroblasts WI-38

Source & Reference

NA
DBAASP
Synthetic molecular evolution of host cell-compatible, antimicrobial peptides effective against drug-resistant, biofilm-forming bacteria. | Proc Natl Acad Sci U S A | 2020
Evidence 3 Activity

Activity

20% Hemolysis
Toxicity
15 µM
Hemolytic Cytotoxic
20% Hemolysis | 15 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Broad-spectrum antimicrobial peptides by rational combinatorial design and high-throughput screening: the importance of interfacial activity | J Am Chem Soc | 2009
Evidence 4 Activity

Activity

3% Hemolysis
Toxicity
15 µM
Hemolytic Cytotoxic
3% Hemolysis | 15 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Broad-spectrum antimicrobial peptides by rational combinatorial design and high-throughput screening: the importance of interfacial activity | J Am Chem Soc | 2009
Evidence 5 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis