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Peptide record

TPDB06772

Antibacterial Anticancer Antifungal Toxicity standard

12 amino acids

3D PDB MODEL

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TPDB ID TPDB06772

Activity

Antibacterial Anticancer Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 12-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

RLRRIVVIRVRR

FASTA

>TPDB06772|Antibacterial;Anticancer;Antifungal;Toxicity|length=12
RLRRIVVIRVRR

Formula C69H134N30O13

Absent Amino Acids ANDCEQGHKMFPSTWY

Common Amino Acids R

Mass 1592.02

PI 13.10

Basic Residues 6

Acidic Residues 0

Hydrophobic Residues 6

Net Charge +6

Boman Index 3.89

Hydrophobicity -0.133

Aliphatic Index 170.00

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

Amino Acid Distribution

A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 3

Length

Formula

C69H134N30O13

Mass

1592.02

13.10

Net Charge

Boman Index

3.89

Hydrophobicity

-0.133

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µM

Target

Target Organism Pseudomonas aeruginosa H103

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

active against P. aeruginosa H103 (MIC 8 uM), E. coli (MIC 2 uM), S. enterica ssp. Typhimurium or S. Typhimurium (MIC 8 uM). S. aureus

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against P. aeruginosa H103 (MIC 8 uM), E. coli (MIC 2 uM), S. enterica ssp. Typhimurium or S. Typhimurium (MIC 8 uM). S. aureus ATCC25923 (MIC 8 uM

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µM

Target

Target Organism S. Typhimurium

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

gainst P. aeruginosa H103 (MIC 8 uM), E. coli (MIC 2 uM), S. enterica ssp. Typhimurium or S. Typhimurium (MIC 8 uM). S. aureus ATCC25923 (MIC 8 uM), S. epidermidis clinical strain (MIC 2 uM), E. faecalis A

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µM

Target

Target Organism Staphylococcus aureus ATCC25923

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

MIC 8 uM), E. coli (MIC 2 uM), S. enterica ssp. Typhimurium or S. Typhimurium (MIC 8 uM). S. aureus ATCC25923 (MIC 8 uM), S. epidermidis clinical strain (MIC 2 uM), E. faecalis ATCC29212 (MIC 4 uM), and C. albi

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µM

Target

Target Organism Staphylococcus epidermidis clinical strain

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

. enterica ssp. Typhimurium or S. Typhimurium (MIC 8 uM). S. aureus ATCC25923 (MIC 8 uM), S. epidermidis clinical strain (MIC 2 uM), E. faecalis ATCC29212 (MIC 4 uM), and C. albicans (MIC 31 uM).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism Enterococcus faecalis ATCC29212

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

um (MIC 8 uM). S. aureus ATCC25923 (MIC 8 uM), S. epidermidis clinical strain (MIC 2 uM), E. faecalis ATCC29212 (MIC 4 uM), and C. albicans (MIC 31 uM).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 31 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

C 8 uM), S. epidermidis clinical strain (MIC 2 uM), E. faecalis ATCC29212 (MIC 4 uM), and C. albicans (MIC 31 uM).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8 µM

Target

Target Organism Pseudomonas aeruginosa H103

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

active against P. aeruginosa H103 (MIC 8 uM), E. coli (MIC 2 uM), S. enterica ssp. Typhimurium or S. Typhimurium (MIC 8 uM). S. aureus

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

active against P. aeruginosa H103 (MIC 8 uM), E. coli (MIC 2 uM), S. enterica ssp. Typhimurium or S. Typhimurium (MIC 8 uM). S. aureus ATCC25923 (MIC 8 uM

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8 µM

Target

Target Organism S. Typhimurium

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8 µM

Target

Target Organism Staphylococcus aureus ATCC25923

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µM

Target

Target Organism Staphylococcus epidermidis clinical strain

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

. enterica ssp. Typhimurium or S. Typhimurium (MIC 8 uM). S. aureus ATCC25923 (MIC 8 uM), S. epidermidis clinical strain (MIC 2 uM), E. faecalis ATCC29212 (MIC 4 uM), and C. albicans (MIC 31 uM).

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µM

Target

Target Organism Enterococcus faecalis ATCC29212

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

um (MIC 8 uM). S. aureus ATCC25923 (MIC 8 uM), S. epidermidis clinical strain (MIC 2 uM), E. faecalis ATCC29212 (MIC 4 uM), and C. albicans (MIC 31 uM).

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 31 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

C 8 uM), S. epidermidis clinical strain (MIC 2 uM), E. faecalis ATCC29212 (MIC 4 uM), and C. albicans (MIC 31 uM).

Evidence 15 Activity

Activity

Activity Endpoint <10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 400 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

<10% Hemolysis | 400 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Linear bactenecin analogs with cell selectivity and anti-endotoxic activity. | J Pept Sci | 2012