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Peptide record

TPDB06736

Antibacterial Antifungal Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB06736
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
IRVKIRVKIRVK
Physicochemical Analysis
C69H134N24O13
ANDCEQGHLMFPSTWY
RIKV
1507.98
12.71
6
0
6
+6
4.68
0.075
170.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
3
I
0
L
3
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 3 L: 0 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 3
Chemical Descriptors
12
C69H134N24O13
1507.98
12.71
+6
4.68
0.075
Evidence Records 3 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
>125 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | >125 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Effect of stereochemistry, chain length and sequence pattern on antimicrobial properties of short synthetic β-sheet forming peptide amphiphiles | Biomaterials | 2014
Evidence 2 Activity

Activity

10% Hemolysis
Toxicity
1250 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 1250 | µg/mL | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Short Synthetic β-Sheet Forming Peptide Amphiphiles as Broad Spectrum Antimicrobials with Antibiofilm and Endotoxin Neutralizing Capabilities. | Adv Funct Mater | 2013
Evidence 3 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.24211081] HC10>125 mg/L against rabbit red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Biomaterials. 2014 Jan 35(4):1315-25. doi: 10.1016/j.biomaterials.2013.10.053.