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Peptide record

TPDB06726

Antibacterial Anticancer Antifungal Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB06726
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF CAFPdb
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AntiCP 2.0, and other sources, with an available 3D structural model.
Sequence
GKWMSLLKHWLK
Physicochemical Analysis
C74H115N19O14S1
ARNDCEQIFPTYV
LK
1526.91
10.84
4
0
6
+3
-1.54
-0.383
97.50
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11000
720.41
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
1
H
0
I
3
L
3
K
1
M
0
F
0
P
1
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 0 L: 3 K: 3 M: 1 F: 0 P: 0 S: 1 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
12
C74H115N19O14S1
1526.91
10.84
+3
-1.54
-0.383
Evidence Records 4 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
106 µM
Hemolytic Cytotoxic
50% Hemolysis | 106 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Evidence 2 Activity

Activity

IC50
Toxicity
40±1 µM
Cytotoxic
IC50 | 40±1 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells. | Peptides | 2012
Evidence 3 Activity

Activity

IC50
Toxicity
78±10 µM
Cytotoxic
IC50 | 78±10 | µM | target cell: Rat epithelial cells IEC-6, CRL-1592

Target

Rat epithelial cells IEC-6, CRL-1592

Source & Reference

NA
DBAASP
Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells. | Peptides | 2012
Evidence 4 Activity

Activity

IC50
Toxicity
106 µM
Hemolytic Cytotoxic
Hemolytic_activity: Rat erythrocytes: IC50=106 µM | Cytotoxicity: HUVEC: IC50=40±1 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2012 Jan 33(1):18-26.