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Peptide record

TPDB06722

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB06722
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF Antifungipept CAFPdb dbAMP PD_Hemolysis
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, ACP740 _ACP240, and other sources, with an available 3D structural model.
Sequence
GKWLSLLKHILK
Physicochemical Analysis
C70H118N18O14
ARNDCEQMFPTYV
L
1435.82
10.84
4
0
6
+3
-0.33
0.225
162.50
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
383.06
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
1
H
1
I
4
L
3
K
0
M
0
F
0
P
1
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 1 L: 4 K: 3 M: 0 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
12
C70H118N18O14
1435.82
10.84
+3
-0.33
0.225
Evidence Records 7 records
Evidence 1 Activity

Activity

IC50
Hemolysis
65 µM
Rat erythrocytes: IC50=65 µM

Target

Rat erythrocytes

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Peptides. 2012 Jan 33(1):18-26.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
65 µM
Hemolytic Cytotoxic
50% Hemolysis | 65 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Evidence 3 Activity

Activity

IC50
Toxicity
42±3 µM
Cytotoxic
IC50 | 42±3 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells. | Peptides | 2012
Evidence 4 Activity

Activity

IC50
Toxicity
40 µM
Cytotoxic
IC50 | 40 | µM | target cell: Rat epithelial cells IEC-6, CRL-1592

Target

Rat epithelial cells IEC-6, CRL-1592

Source & Reference

NA
DBAASP
Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells. | Peptides | 2012
Evidence 5 Activity

Activity

IC50
Toxicity
21.6±2.4 µM
Cytotoxic
IC50 | 21.6±2.4 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Lipopeptisomes: Anticancer peptide-assembled particles for fusolytic oncotherapy. | Acta Biomater | 2018
Evidence 6 Activity

Activity

IC50
Toxicity
65 µM
Hemolytic Cytotoxic
Hemolytic_activity: Rat erythrocytes: IC50=65 µM | Cytotoxicity: HUVEC: IC50=42±3 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2012 Jan 33(1):18-26.
Evidence 7 Hemolysis

Activity

65 µM
IC50
Rat erythrocytes: IC50=65 µM
Hemolysis

Target

Rat erythrocytes

Source & Reference

PD_Hemolysis
Peptides. 2012 Jan 33(1):18-26.
DRAMP4
PD_Hemolysis