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Peptide record

TPDB06711

Antibacterial Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB06711
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 12-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GIHDALKYGKPS
Physicochemical Analysis
C58H92N16O17
RNCEQMFTWV
GK
1285.47
9.65
3
1
4
+1
2.79
-0.742
73.33
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
115.91
2
Residue Composition
number
1
A
0
R
0
N
1
D
0
C
0
E
0
Q
2
G
1
H
1
I
1
L
2
K
0
M
0
F
1
P
1
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 2 H: 1 I: 1 L: 1 K: 2 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
12
C58H92N16O17
1285.47
9.65
+1
2.79
-0.742
Evidence Records 7 records
Evidence 1 Activity

Activity

MIC
Antibacterial
20 µM

Target

Escherichia coli ATCC 11219

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against E. coli ATCC 11219 (MIC 20 uM), P. aeruginosa ATCC 13388 (MIC 10 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC 2.
Evidence 2 Activity

Activity

MIC
Antibacterial
10 µM

Target

Pseudomonas aeruginosa ATCC 13388

Source & Reference

dbAMP DRAMP

Other

active against E. coli ATCC 11219 (MIC 20 uM), P. aeruginosa ATCC 13388 (MIC 10 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC 2.2 uM), K. pneumoniae ATCC 10031 (MIC 2
Evidence 3 Activity

Activity

MIC
Antibacterial
2.2 µM

Target

S. enterica serovar Typhimurium ATCC 14028

Source & Reference

dbAMP DRAMP

Other

active against E. coli ATCC 11219 (MIC 20 uM), P. aeruginosa ATCC 13388 (MIC 10 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC 2.2 uM), K. pneumoniae ATCC 10031 (MIC 20 uM), S. aureus ATCC 6538 (MIC 5 uM).
Evidence 4 Activity

Activity

MIC
Antibacterial
20 µM

Target

Klebsiella pneumoniae ATCC 10031

Source & Reference

dbAMP DRAMP

Other

ruginosa ATCC 13388 (MIC 10 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC 2.2 uM), K. pneumoniae ATCC 10031 (MIC 20 uM), S. aureus ATCC 6538 (MIC 5 uM).
Evidence 5 Activity

Activity

MIC
Antibacterial
5 µM

Target

Staphylococcus aureus ATCC 6538

Source & Reference

dbAMP DRAMP

Other

terica serovar Typhimurium ATCC 14028 (MIC 2.2 uM), K. pneumoniae ATCC 10031 (MIC 20 uM), S. aureus ATCC 6538 (MIC 5 uM).
Evidence 6 Activity

Activity

10% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
10% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structural insights into and activity analysis of the antimicrobial peptide myxinidin. | Antimicrob Agents Chemother | 2014
Evidence 7 Activity

Activity

% Hemolysis
Toxicity
10 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.24957834] Some peptides at 50 µM led to about 10% hemolysis against human red blood cells, but in general, negligible hemolytic activity is observed even at 100 µM and 200 µM peptide. | Cytotoxicity: [Ref.24957834] The toxicity of the peptide against Vero cells is 0.7%, 0.7%, 4%, 11.7% and 20% at peptide concentrations of 1, 20, 50, 100 and 200 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
Antimicrob Agents Chemother. 2014 Sep 58(9):5280-90.