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Peptide record

TPDB06709

Antibacterial Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB06709
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 12-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GIADILKYGKPS
Physicochemical Analysis
C58H96N14O17
RNCEQHMFTWV
GIK
1261.48
9.65
2
1
5
+1
1.52
-0.100
105.83
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
118.11
2
Residue Composition
number
1
A
0
R
0
N
1
D
0
C
0
E
0
Q
2
G
0
H
2
I
1
L
2
K
0
M
0
F
1
P
1
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 1 K: 2 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
12
C58H96N14O17
1261.48
9.65
+1
1.52
-0.100
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
15 µM

Target

Pseudomonas aeruginosa ATCC 13388

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against E-coli ATCC 11219 (MIC >50 uM), P. aeruginosa ATCC 13388 (MIC 15 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC 10 uM), K. pneumoniae ATCC 10031 (MIC 30
Evidence 2 Activity

Activity

MIC
Antibacterial
10 µM

Target

S. enterica serovar Typhimurium ATCC 14028

Source & Reference

dbAMP DRAMP

Other

active against E-coli ATCC 11219 (MIC >50 uM), P. aeruginosa ATCC 13388 (MIC 15 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC 10 uM), K. pneumoniae ATCC 10031 (MIC 30 uM), S. aureus ATCC 6538 (MIC 20 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
30 µM

Target

Klebsiella pneumoniae ATCC 10031

Source & Reference

dbAMP DRAMP

Other

eruginosa ATCC 13388 (MIC 15 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC 10 uM), K. pneumoniae ATCC 10031 (MIC 30 uM), S. aureus ATCC 6538 (MIC 20 uM).
Evidence 4 Activity

Activity

MIC
Antibacterial
20 µM

Target

Staphylococcus aureus ATCC 6538

Source & Reference

dbAMP DRAMP

Other

nterica serovar Typhimurium ATCC 14028 (MIC 10 uM), K. pneumoniae ATCC 10031 (MIC 30 uM), S. aureus ATCC 6538 (MIC 20 uM).
Evidence 5 Activity

Activity

12% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
12% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structural insights into and activity analysis of the antimicrobial peptide myxinidin. | Antimicrob Agents Chemother | 2014
Evidence 6 Activity

Activity

% Hemolysis
Toxicity
10 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.24957834] Some peptides at 50 µM led to about 10% hemolysis against human red blood cells, but in general, negligible hemolytic activity is observed even at 100 µM and 200 µM peptide. | Cytotoxicity: [Ref.24957834] The toxicity of the peptide against Vero cells is 0.7%, 0.7%, 4.9%,12% and 20% at peptide concentrations of 1, 20, 50, 100 and 200 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
Antimicrob Agents Chemother. 2014 Sep 58(9):5280-90.